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The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.

Henkel, Michael ; Mitzner, David ; Henklein, Peter ; Meyer-Almes, Franz-Josef ; Moroni, Anna ; Difrancesco, Mattia L. ; Henkes, Leonhard M. ; Kreim, Michael ; Kast, Stefan M. ; Schubert, Ulrich ; Thiel, Gerhard (2010):
The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.
In: PloS one, 5 (6), pp. e11112. ISSN 1932-6203,
[Article]

Abstract

The data support the idea that PB1-F2 is able to form protein channel pores with no appreciable selectivity in membranes and that the c-terminus is important for this function. This information could be important for drug development.

Item Type: Article
Erschienen: 2010
Creators: Henkel, Michael ; Mitzner, David ; Henklein, Peter ; Meyer-Almes, Franz-Josef ; Moroni, Anna ; Difrancesco, Mattia L. ; Henkes, Leonhard M. ; Kreim, Michael ; Kast, Stefan M. ; Schubert, Ulrich ; Thiel, Gerhard
Title: The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.
Language: English
Abstract:

The data support the idea that PB1-F2 is able to form protein channel pores with no appreciable selectivity in membranes and that the c-terminus is important for this function. This information could be important for drug development.

Journal or Publication Title: PloS one
Journal Volume: 5
Issue Number: 6
Divisions: 10 Department of Biology > Plant Membrane Biophysics
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10 Department of Biology
Date Deposited: 21 Jun 2011 11:56
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