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Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4.

Warzecha, Heribert and Ferme, D. and Peer, M. and Frank, A. and Unger, M. (2010):
Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4.
In: Journal of bioscience and bioengineering, 109 (3), pp. 288-90. ISSN 1347-4421,
[Article]

Abstract

In this study we have expanded the metabolic potential of plant cell suspension cultures by introducing active human cytochrome P450 monooxygenase 3A4 into tobacco cells. Exogenously supplied loratadine was metabolized in a 3A4-specific manner, showing the capacity of this system for the generation of metabolites.

Item Type: Article
Erschienen: 2010
Creators: Warzecha, Heribert and Ferme, D. and Peer, M. and Frank, A. and Unger, M.
Title: Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4.
Language: English
Abstract:

In this study we have expanded the metabolic potential of plant cell suspension cultures by introducing active human cytochrome P450 monooxygenase 3A4 into tobacco cells. Exogenously supplied loratadine was metabolized in a 3A4-specific manner, showing the capacity of this system for the generation of metabolites.

Journal or Publication Title: Journal of bioscience and bioengineering
Journal volume: 109
Number: 3
Divisions: 10 Department of Biology > Plant Biotechnology and Metabolic Engineering
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10 Department of Biology
Date Deposited: 17 Mar 2011 12:33
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