TU Darmstadt / ULB / TUbiblio

Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.

Glenz, K. and Bouchon, B. and Stehle, T. and Wallich, R. and Simon, M. M. and Warzecha, Heribert (2006):
Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.
In: Nature biotechnology, 24 (1), pp. 76-7. ISSN 1087-0156,
[Article]

Abstract

Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.

Item Type: Article
Erschienen: 2006
Creators: Glenz, K. and Bouchon, B. and Stehle, T. and Wallich, R. and Simon, M. M. and Warzecha, Heribert
Title: Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.
Language: English
Abstract:

Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.

Journal or Publication Title: Nature biotechnology
Journal volume: 24
Number: 1
Divisions: 10 Department of Biology > Plant Biotechnology and Metabolic Engineering
?? fb10_botanik ??
10 Department of Biology
Date Deposited: 17 Mar 2011 11:01
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details