Niswander, L. ; Tickle, C. ; Vogel, A. ; Booth, I. ; Martin, G. R. (1993)
FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb.
In: Cell, 75 (3)
Article, Bibliographie
Abstract
The apical ectodermal ridge plays a key role in limb development. We show that recombinant FGF-4 can substitute for the ridge to provide all the signals necessary for virtually complete outgrowth and patterning of the chick limb. FGF-4 stimulates proliferation of cells in the distal mesenchyme and maintains a signal from the posterior to the distal mesenchyme that appears to be required for elaboration of skeletal elements in the normal proximodistal sequence. Moreover, retinoic acid, which is capable of providing polarizing activity, can supply this signal. This suggests that polarizing activity plays a role in patterning along the proximodistal axis, in addition to its well-established role in anteroposterior patterning. Taken together, the data suggest a simple mechanism whereby FGF-4 links growth and pattern formation during limb development.
| Item Type: | Article |
|---|---|
| Erschienen: | 1993 |
| Creators: | Niswander, L. ; Tickle, C. ; Vogel, A. ; Booth, I. ; Martin, G. R. |
| Type of entry: | Bibliographie |
| Title: | FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. |
| Language: | English |
| Date: | 1993 |
| Journal or Publication Title: | Cell |
| Volume of the journal: | 75 |
| Issue Number: | 3 |
| Corresponding Links: | |
| Abstract: | The apical ectodermal ridge plays a key role in limb development. We show that recombinant FGF-4 can substitute for the ridge to provide all the signals necessary for virtually complete outgrowth and patterning of the chick limb. FGF-4 stimulates proliferation of cells in the distal mesenchyme and maintains a signal from the posterior to the distal mesenchyme that appears to be required for elaboration of skeletal elements in the normal proximodistal sequence. Moreover, retinoic acid, which is capable of providing polarizing activity, can supply this signal. This suggests that polarizing activity plays a role in patterning along the proximodistal axis, in addition to its well-established role in anteroposterior patterning. Taken together, the data suggest a simple mechanism whereby FGF-4 links growth and pattern formation during limb development. |
| Divisions: | 10 Department of Biology > Developmental Biology and Neurogenetics ?? fb10_zoologie ?? 10 Department of Biology |
| Date Deposited: | 24 Jan 2011 10:40 |
| Last Modified: | 05 Mar 2013 09:44 |
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