TU Darmstadt / ULB / TUbiblio

A novel isoform of the smooth muscle cell differentiation marker smoothelin.

Krämer, J. ; Aguirre-Arteta, A. M. ; Thiel, C. ; Gross, C. M. ; Dietz, R. ; Cardoso, M. Cristina ; Leonhardt, H. (1999)
A novel isoform of the smooth muscle cell differentiation marker smoothelin.
In: Journal of molecular medicine, 77 (2)
Article, Bibliographie

Abstract

Studies on smooth muscle cell differentiation and those on vascular development in mouse and humans have long been hampered by the lack of suitable markers. Here we describe a novel, large isoform of smoothelin, a structural protein of differentiated, contractile smooth muscle cells. The protein, which is highly conserved in mouse and humans, shows homology with other cytoskeleton-associated smooth muscle cell proteins and contains an actinin-type actin-binding domain. Northern blot analysis from various mouse organs identified short and long smoothelin mRNA forms, which exhibit distinct tissue expression patterns. The short form is highly expressed in visceral muscle tissues such as intestine and stomach and is not detectable in brain, while the long mRNA form is expressed in all vascularized organs. These results may provide new tools and approaches to study both smooth muscle cell differentiation and proliferative vascular disease.

Item Type: Article
Erschienen: 1999
Creators: Krämer, J. ; Aguirre-Arteta, A. M. ; Thiel, C. ; Gross, C. M. ; Dietz, R. ; Cardoso, M. Cristina ; Leonhardt, H.
Type of entry: Bibliographie
Title: A novel isoform of the smooth muscle cell differentiation marker smoothelin.
Language: German
Date: 1999
Journal or Publication Title: Journal of molecular medicine
Volume of the journal: 77
Issue Number: 2
URL / URN: http://www.cardoso-lab.org/publications/Kraemer_1999.PDF
Abstract:

Studies on smooth muscle cell differentiation and those on vascular development in mouse and humans have long been hampered by the lack of suitable markers. Here we describe a novel, large isoform of smoothelin, a structural protein of differentiated, contractile smooth muscle cells. The protein, which is highly conserved in mouse and humans, shows homology with other cytoskeleton-associated smooth muscle cell proteins and contains an actinin-type actin-binding domain. Northern blot analysis from various mouse organs identified short and long smoothelin mRNA forms, which exhibit distinct tissue expression patterns. The short form is highly expressed in visceral muscle tissues such as intestine and stomach and is not detectable in brain, while the long mRNA form is expressed in all vascularized organs. These results may provide new tools and approaches to study both smooth muscle cell differentiation and proliferative vascular disease.

Divisions: 10 Department of Biology
?? fb10_zoologie ??
10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 05 Mar 2010 15:52
Last Modified: 06 Jul 2018 09:51
PPN:
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details