Richter, Merle ; Loth, Yannik ; Weisenstein, Christian ; Wigger, Anna Katharina ; Schaar, Dominik ; Bosserhoff, Anja Katrin ; Haring Bolívar, Peter (2022)
Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics.
In: Frequenz, 76 (11-12)
doi: 10.1515/freq-2022-0092
Article, Bibliographie
This is the latest version of this item.
Abstract
Terahertz (THz) biosensing has emerged as an important research field, mainly driven by the resonant behavior of many biomolecules in this spectral range which holds potential for highly sensitive analyses. In this work, we present a detailed overview of our current research on THz biosensing, focusing on the development and analysis of THz biosensors based on frequency selective surfaces (FSS) for two different measurement scenarios: i) label-free, highly sensitive and selective analysis of dried biomolecules, and ii) sensitive and selective analysis in an aqueous environment. With our carefully designed THz biosensor for measurements in the dry state, we were able to indirectly measure tumor-marker MIA RNA in a concentration as low as 1.55 × 1E−12 mol/L, without the need for biochemical amplification. Our biosensor with substrate-integrated microfluidics for terahertz measurements in an aqueous environment is validated by simulations, showing that the resonance feature in the frequency response of our sensor is maintained even for measurements in water.
| Item Type: | Article |
|---|---|
| Erschienen: | 2022 |
| Creators: | Richter, Merle ; Loth, Yannik ; Weisenstein, Christian ; Wigger, Anna Katharina ; Schaar, Dominik ; Bosserhoff, Anja Katrin ; Haring Bolívar, Peter |
| Type of entry: | Bibliographie |
| Title: | Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics |
| Language: | English |
| Date: | 2022 |
| Place of Publication: | Darmstadt |
| Publisher: | De Gruyter |
| Journal or Publication Title: | Frequenz |
| Volume of the journal: | 76 |
| Issue Number: | 11-12 |
| DOI: | 10.1515/freq-2022-0092 |
| Corresponding Links: | |
| Abstract: | Terahertz (THz) biosensing has emerged as an important research field, mainly driven by the resonant behavior of many biomolecules in this spectral range which holds potential for highly sensitive analyses. In this work, we present a detailed overview of our current research on THz biosensing, focusing on the development and analysis of THz biosensors based on frequency selective surfaces (FSS) for two different measurement scenarios: i) label-free, highly sensitive and selective analysis of dried biomolecules, and ii) sensitive and selective analysis in an aqueous environment. With our carefully designed THz biosensor for measurements in the dry state, we were able to indirectly measure tumor-marker MIA RNA in a concentration as low as 1.55 × 1E−12 mol/L, without the need for biochemical amplification. Our biosensor with substrate-integrated microfluidics for terahertz measurements in an aqueous environment is validated by simulations, showing that the resonance feature in the frequency response of our sensor is maintained even for measurements in water. |
| Uncontrolled Keywords: | biomedical spectroscopy, biosensing, fano resonance, metamaterial, microfluidics, terahertz |
| Classification DDC: | 500 Science and mathematics > 530 Physics 500 Science and mathematics > 570 Life sciences, biology 600 Technology, medicine, applied sciences > 600 Technology 600 Technology, medicine, applied sciences > 620 Engineering and machine engineering |
| Divisions: | 18 Department of Electrical Engineering and Information Technology 18 Department of Electrical Engineering and Information Technology > Institute for Microwave Engineering and Photonics (IMP) |
| Date Deposited: | 02 Aug 2024 12:50 |
| Last Modified: | 30 Aug 2024 07:51 |
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| Suche nach Titel in: | TUfind oder in Google |
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Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics. (deposited 01 Mar 2023 10:15)
- Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics. (deposited 02 Aug 2024 12:50) [Currently Displayed]
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