Abdighahroudi, Mohammad Sajjad ; Lutze, Holger V. ; Schmidt, Torsten C. (2020)
Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography.
In: Analytical and Bioanalytical Chemistry, 412 (20)
doi: 10.1007/s00216-020-02665-x
Article, Bibliographie
This is the latest version of this item.
Abstract
N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation.
| Item Type: | Article |
|---|---|
| Erschienen: | 2020 |
| Creators: | Abdighahroudi, Mohammad Sajjad ; Lutze, Holger V. ; Schmidt, Torsten C. |
| Type of entry: | Bibliographie |
| Title: | Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography |
| Language: | English |
| Date: | 2020 |
| Publisher: | Springer |
| Journal or Publication Title: | Analytical and Bioanalytical Chemistry |
| Volume of the journal: | 412 |
| Issue Number: | 20 |
| DOI: | 10.1007/s00216-020-02665-x |
| Corresponding Links: | |
| Abstract: | N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation. |
| Classification DDC: | 600 Technology, medicine, applied sciences > 600 Technology 600 Technology, medicine, applied sciences > 620 Engineering and machine engineering |
| Divisions: | 13 Department of Civil and Environmental Engineering Sciences 13 Department of Civil and Environmental Engineering Sciences > Institute IWAR |
| Date Deposited: | 02 Aug 2024 12:38 |
| Last Modified: | 02 Aug 2024 12:38 |
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| Suche nach Titel in: | TUfind oder in Google |
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Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography. (deposited 03 Mar 2022 13:34)
- Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography. (deposited 02 Aug 2024 12:38) [Currently Displayed]
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