Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas (2022)
Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study.
In: Crystals, 10 (5)
doi: 10.3390/cryst10050401
Article, Bibliographie
This is the latest version of this item.
Abstract
β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.
| Item Type: | Article |
|---|---|
| Erschienen: | 2022 |
| Creators: | Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas |
| Type of entry: | Bibliographie |
| Title: | Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study |
| Language: | English |
| Date: | 2022 |
| Publisher: | MDPI |
| Journal or Publication Title: | Crystals |
| Volume of the journal: | 10 |
| Issue Number: | 5 |
| Collation: | 15 Seiten |
| DOI: | 10.3390/cryst10050401 |
| Corresponding Links: | |
| Abstract: | β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures. |
| Uncontrolled Keywords: | saponin, β-aescin, β-escin, lipid membrane, bicelle, nanodisk, wide-angle X-ray scattering, biosurfactant, ibuprofen |
| Classification DDC: | 500 Science and mathematics > 530 Physics 500 Science and mathematics > 540 Chemistry |
| Divisions: | 05 Department of Physics 05 Department of Physics > Institute for Condensed Matter Physics 05 Department of Physics > Institute for Condensed Matter Physics > Soft Matter at Interfaces (SMI) |
| Date Deposited: | 02 Aug 2024 12:37 |
| Last Modified: | 02 Aug 2024 12:37 |
| PPN: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
Available Versions of this Item
-
Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. (deposited 09 Feb 2022 15:18)
- Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. (deposited 02 Aug 2024 12:37) [Currently Displayed]
 |
Send an inquiry |
Options (only for editors)
 |
Show editorial Details |
Drucken
Impressum