TU Darmstadt / ULB / TUbiblio

Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor

Tinganelli, Walter ; Hitrec, Timna ; Romani, Fabrizio ; Simoniello, Palma ; Squarcio, Fabio ; Stanzani, Agnese ; Piscitiello, Emiliana ; Marchesano, Valentina ; Luppi, Marco ; Sioli, Maximiliano ; Helm, Alexander ; Compagnone, Gaetano ; Morganti, Alessio G. ; Amici, Roberto ; Negrini, Matteo ; Zoccoli, Antonio ; Durante, Marco ; Cerri, Matteo (2019)
Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor.
In: International Journal of Molecular Sciences, 20 (2)
doi: 10.3390/ijms20020352
Article, Bibliographie

This is the latest version of this item.

Abstract

Hibernation has been proposed as a tool for human space travel. In recent years, a procedure to induce a metabolic state known as "synthetic torpor" in non-hibernating mammals was successfully developed. Synthetic torpor may not only be an efficient method to spare resources and reduce psychological problems in long-term exploratory-class missions, but may also represent a countermeasure against cosmic rays. Here we show the preliminary results from an experiment in rats exposed to ionizing radiation in normothermic conditions or synthetic torpor. Animals were irradiated with 3 Gy X-rays and organs were collected 4 h after exposure. Histological analysis of liver and testicle showed a reduced toxicity in animals irradiated in torpor compared to controls irradiated at normal temperature and metabolic activity. The expression of ataxia telangiectasia mutated (ATM) in the liver was significantly downregulated in the group of animal in synthetic torpor. In the testicle, more genes involved in the DNA damage signaling were downregulated during synthetic torpor. These data show for the first time that synthetic torpor is a radioprotector in non-hibernators, similarly to natural torpor in hibernating animals. Synthetic torpor can be an effective strategy to protect humans during long term space exploration of the solar system.

Item Type: Article
Erschienen: 2019
Creators: Tinganelli, Walter ; Hitrec, Timna ; Romani, Fabrizio ; Simoniello, Palma ; Squarcio, Fabio ; Stanzani, Agnese ; Piscitiello, Emiliana ; Marchesano, Valentina ; Luppi, Marco ; Sioli, Maximiliano ; Helm, Alexander ; Compagnone, Gaetano ; Morganti, Alessio G. ; Amici, Roberto ; Negrini, Matteo ; Zoccoli, Antonio ; Durante, Marco ; Cerri, Matteo
Type of entry: Bibliographie
Title: Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor
Language: English
Date: 2019
Place of Publication: Basel
Publisher: MDPI
Journal or Publication Title: International Journal of Molecular Sciences
Volume of the journal: 20
Issue Number: 2
Collation: 12 Seiten
DOI: 10.3390/ijms20020352
Corresponding Links:
Abstract:

Hibernation has been proposed as a tool for human space travel. In recent years, a procedure to induce a metabolic state known as "synthetic torpor" in non-hibernating mammals was successfully developed. Synthetic torpor may not only be an efficient method to spare resources and reduce psychological problems in long-term exploratory-class missions, but may also represent a countermeasure against cosmic rays. Here we show the preliminary results from an experiment in rats exposed to ionizing radiation in normothermic conditions or synthetic torpor. Animals were irradiated with 3 Gy X-rays and organs were collected 4 h after exposure. Histological analysis of liver and testicle showed a reduced toxicity in animals irradiated in torpor compared to controls irradiated at normal temperature and metabolic activity. The expression of ataxia telangiectasia mutated (ATM) in the liver was significantly downregulated in the group of animal in synthetic torpor. In the testicle, more genes involved in the DNA damage signaling were downregulated during synthetic torpor. These data show for the first time that synthetic torpor is a radioprotector in non-hibernators, similarly to natural torpor in hibernating animals. Synthetic torpor can be an effective strategy to protect humans during long term space exploration of the solar system.

Uncontrolled Keywords: radiation, liver, testicle, synthetic torpor, torpor, hypothermia, hibernation, raphe pallidus, ATM, space exploration
Additional Information:

Erstveröffentlichung; This article belongs to the Special Issue Adaptation of Living Organisms in Space: From Mammals to Plants

Classification DDC: 500 Science and mathematics > 530 Physics
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 05 Department of Physics
05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 15 May 2024 14:45
Last Modified: 15 May 2024 14:45
PPN:
Export:
Suche nach Titel in: TUfind oder in Google

Available Versions of this Item

Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details