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Vom Huhn abgeleitete Antikörper für Diagnostik und Immuntherapie

Elter, Adrian ; Bogen, Jan P. ; Habermann, Jan ; Kolmar, Harald (2021)
Vom Huhn abgeleitete Antikörper für Diagnostik und Immuntherapie.
In: BIOspektrum : Das Magazin für Biowissenschaften, 27 (5)
doi: 10.1007/s12268-021-1623-3
Article, Bibliographie

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Abstract

Due to the large evolutionary distance between birds (Aves) und humans, immunization of chickens with human proteins results in a strong response of the bird’s adaptive immune system to proteins of mammalian origin. Additionally, chicken-derived antibodies display less undesired cross-reactivity in analytical setups than conventional rodent-derived antibodies. Due to these features as well as the facile amplification of antibody-coding genes, chicken-derived antibodies emerged as promising molecules for the immunotherapy and various biotechnological applications.

Item Type: Article
Erschienen: 2021
Creators: Elter, Adrian ; Bogen, Jan P. ; Habermann, Jan ; Kolmar, Harald
Type of entry: Bibliographie
Title: Vom Huhn abgeleitete Antikörper für Diagnostik und Immuntherapie
Language: German
Date: September 2021
Place of Publication: Berlin ; Heidelberg
Publisher: Springer
Journal or Publication Title: BIOspektrum : Das Magazin für Biowissenschaften
Volume of the journal: 27
Issue Number: 5
DOI: 10.1007/s12268-021-1623-3
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Abstract:

Due to the large evolutionary distance between birds (Aves) und humans, immunization of chickens with human proteins results in a strong response of the bird’s adaptive immune system to proteins of mammalian origin. Additionally, chicken-derived antibodies display less undesired cross-reactivity in analytical setups than conventional rodent-derived antibodies. Due to these features as well as the facile amplification of antibody-coding genes, chicken-derived antibodies emerged as promising molecules for the immunotherapy and various biotechnological applications.

Uncontrolled Keywords: Life Sciences, general, Biochemistry, general, Human Genetics, Microbiology, Pharmacology/Toxicology
Classification DDC: 500 Science and mathematics > 540 Chemistry
500 Science and mathematics > 570 Life sciences, biology
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Clemens-Schöpf-Institut > Fachgebiet Biochemie
07 Department of Chemistry > Clemens-Schöpf-Institut
Date Deposited: 02 May 2024 10:15
Last Modified: 02 May 2024 10:15
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