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Radioactive Beams in Particle Therapy: Past, Present, and Future

Durante, Marco ; Parodi, Katia (2020)
Radioactive Beams in Particle Therapy: Past, Present, and Future.
In: Frontiers in Physics, 8
doi: 10.3389/fphy.2020.00326
Article, Bibliographie

This is the latest version of this item.

Abstract

Heavy ion therapy can deliver high doses with high precision. However, image guidance is needed to reduce range uncertainty. Radioactive ions are potentially ideal projectiles for radiotherapy because their decay can be used to visualize the beam. Positron-emitting ions that can be visualized with PET imaging were already studied for therapy application during the pilot therapy project at the Lawrence Berkeley Laboratory, and later within the EULIMA EU project, the GSI therapy trial in Germany, MEDICIS at CERN, and at HIMAC in Japan. The results show that radioactive ion beams provide a large improvement in image quality and signal-to-noise ratio compared to stable ions. The main hindrance toward a clinical use of radioactive ions is their challenging production and the low intensities of the beams. New research projects are ongoing in Europe and Japan to assess the advantages of radioactive ion beams for therapy, to develop new detectors, and to build sources of radioactive ions for medical synchrotrons.

Item Type: Article
Erschienen: 2020
Creators: Durante, Marco ; Parodi, Katia
Type of entry: Bibliographie
Title: Radioactive Beams in Particle Therapy: Past, Present, and Future
Language: English
Date: 28 August 2020
Place of Publication: Lausanne
Publisher: Frontiers Media S.A.
Journal or Publication Title: Frontiers in Physics
Volume of the journal: 8
Collation: 13 Seiten
DOI: 10.3389/fphy.2020.00326
Corresponding Links:
Abstract:

Heavy ion therapy can deliver high doses with high precision. However, image guidance is needed to reduce range uncertainty. Radioactive ions are potentially ideal projectiles for radiotherapy because their decay can be used to visualize the beam. Positron-emitting ions that can be visualized with PET imaging were already studied for therapy application during the pilot therapy project at the Lawrence Berkeley Laboratory, and later within the EULIMA EU project, the GSI therapy trial in Germany, MEDICIS at CERN, and at HIMAC in Japan. The results show that radioactive ion beams provide a large improvement in image quality and signal-to-noise ratio compared to stable ions. The main hindrance toward a clinical use of radioactive ions is their challenging production and the low intensities of the beams. New research projects are ongoing in Europe and Japan to assess the advantages of radioactive ion beams for therapy, to develop new detectors, and to build sources of radioactive ions for medical synchrotrons.

Uncontrolled Keywords: particle therapy, radioactive ion beams, carbon ions, oxygen ions, PET
Identification Number: Artikel-ID: 326
Additional Information:

This article is part of the Research Topic: Applied Nuclear Physics at Accelerators

Specialty section: This article was submitted to Medical Physics and Imaging, a section of the journal Frontiers in Physics

Classification DDC: 500 Science and mathematics > 530 Physics
Divisions: 05 Department of Physics
05 Department of Physics > Institute for Condensed Matter Physics
Date Deposited: 19 Mar 2024 10:20
Last Modified: 19 Mar 2024 10:20
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