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Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing

Azkune, Mikel ; Frosch, Timea ; Arrospide, Eneko ; Aldabaldetreku, Gotzon ; Bikandi, Inaki ; Zubia, Joseba ; Popp, Jürgen ; Frosch, Torsten (2019)
Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing.
In: Journal of Lightwave Technology, 37 (13)
doi: 10.1109/JLT.2019.2908447
Article, Bibliographie

Abstract

This work reports the development and application of two liquid-core microstructured polymer optical fibers (LC-mPOF) with different microstructure sizes. They are used in a fiber-enhanced Raman spectroscopy sensing platform, with the aim of detecting glucose in aqueous solutions in the clinically relevant range for sodium-glucose cotransporter 2 inhibitor therapy. The sensing platform is tested for low-concentration glucose solutions using each LC-mPOF. Results confirm that a significant enhancement of the Raman signal is achieved in comparison to conventional Raman spectroscopy. Additional measurements are carried out to obtain the valid measurement range, the resolution, and the limit of detection, showing that the LC-mPOF with 66-μm-diameter central hollow core has the highest potential for future clinical applications. Finally, preliminary tests successfully demonstrate glucose identification in urine.

Item Type: Article
Erschienen: 2019
Creators: Azkune, Mikel ; Frosch, Timea ; Arrospide, Eneko ; Aldabaldetreku, Gotzon ; Bikandi, Inaki ; Zubia, Joseba ; Popp, Jürgen ; Frosch, Torsten
Type of entry: Bibliographie
Title: Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
Language: English
Date: 1 July 2019
Publisher: IEEE
Journal or Publication Title: Journal of Lightwave Technology
Volume of the journal: 37
Issue Number: 13
DOI: 10.1109/JLT.2019.2908447
Abstract:

This work reports the development and application of two liquid-core microstructured polymer optical fibers (LC-mPOF) with different microstructure sizes. They are used in a fiber-enhanced Raman spectroscopy sensing platform, with the aim of detecting glucose in aqueous solutions in the clinically relevant range for sodium-glucose cotransporter 2 inhibitor therapy. The sensing platform is tested for low-concentration glucose solutions using each LC-mPOF. Results confirm that a significant enhancement of the Raman signal is achieved in comparison to conventional Raman spectroscopy. Additional measurements are carried out to obtain the valid measurement range, the resolution, and the limit of detection, showing that the LC-mPOF with 66-μm-diameter central hollow core has the highest potential for future clinical applications. Finally, preliminary tests successfully demonstrate glucose identification in urine.

Uncontrolled Keywords: Fiber Enhanced Raman Spectroscopy FERS, Glucose Sensing, Pharma, Therapeutical Drug Monitoring TDM, Sodium-Glucose-Co-transporter 2 (SGLT2) inhibitor, Urine, Bodyfluid, Diabetes, Drug Sensing, Biomedical Sensing, Biomedical Spectroscopy, Pharmaceutical Spectroscopy, hollow core polymer fiber
Divisions: 18 Department of Electrical Engineering and Information Technology
18 Department of Electrical Engineering and Information Technology > Biophotonik-Medizintechnik
Date Deposited: 18 Jan 2024 11:12
Last Modified: 20 Mar 2024 14:13
PPN: 515995665
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