Abdighahroudi, Mohammad Sajjad ; Lutze, Holger V. ; Schmidt, Torsten C. (2022)
Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography.
In: Analytical and Bioanalytical Chemistry, 2020, 412 (20)
doi: 10.26083/tuprints-00013304
Article, Secondary publication, Publisher's Version
Abstract
N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation.
| Item Type: | Article |
|---|---|
| Erschienen: | 2022 |
| Creators: | Abdighahroudi, Mohammad Sajjad ; Lutze, Holger V. ; Schmidt, Torsten C. |
| Type of entry: | Secondary publication |
| Title: | Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography |
| Language: | English |
| Date: | 2022 |
| Year of primary publication: | 2020 |
| Publisher: | Springer |
| Journal or Publication Title: | Analytical and Bioanalytical Chemistry |
| Volume of the journal: | 412 |
| Issue Number: | 20 |
| DOI: | 10.26083/tuprints-00013304 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/13304 |
| Corresponding Links: | |
| Origin: | Secondary publication via DEAL-contract with Springer |
| Abstract: | N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation. |
| Status: | Publisher's Version |
| URN: | urn:nbn:de:tuda-tuprints-133040 |
| Classification DDC: | 600 Technik, Medizin, angewandte Wissenschaften > 600 Technik 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften und Maschinenbau |
| Divisions: | 13 Department of Civil and Environmental Engineering Sciences 13 Department of Civil and Environmental Engineering Sciences > Institute IWAR |
| Date Deposited: | 03 Mar 2022 13:34 |
| Last Modified: | 04 Mar 2022 07:15 |
| PPN: | |
| Corresponding Links: | |
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