TU Darmstadt / ULB / TUbiblio

Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas (2022):
Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study. (Publisher's Version)
In: Crystals, 10 (5), MDPI, e-ISSN 2073-4352,
DOI: 10.26083/tuprints-00016973,
[Article]

Abstract

β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.

Item Type: Article
Erschienen: 2022
Creators: Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas
Origin: Secondary publication
Status: Publisher's Version
Title: Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study
Language: English
Abstract:

β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.

Journal or Publication Title: Crystals
Journal Volume: 10
Issue Number: 5
Publisher: MDPI
Collation: 15 Seiten
Uncontrolled Keywords: saponin, β-aescin, β-escin, lipid membrane, bicelle, nanodisk, wide-angle X-ray scattering, biosurfactant, ibuprofen
Divisions: 05 Department of Physics
05 Department of Physics > Institute for Condensed Matter Physics
05 Department of Physics > Institute for Condensed Matter Physics > Soft Matter at Interfaces (SMI)
Date Deposited: 09 Feb 2022 15:18
DOI: 10.26083/tuprints-00016973
URL / URN: https://tuprints.ulb.tu-darmstadt.de/16973
URN: urn:nbn:de:tuda-tuprints-169736
Corresponding Links:
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details