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Auto- and cross-regulation of the hnRNPs D and DL

Kemmerer, Katrin and Fischer, Sandra and Weigand, Julia E. (2018):
Auto- and cross-regulation of the hnRNPs D and DL.
In: RNA (New York, N.Y.), 24 (3), pp. 324-331. Cold Spring Harbor Laboratory Press / RNA Society, ISSN 1469-9001,
DOI: 10.1261/rna.063420.117,
[Article]

Abstract

HnRNP D, better known as AUF1, is an extensively studied protein that controls a variety of cellular pathways. Consequently, its expression has to be tightly regulated to prevent the onset of pathologies. In contrast, the cellular functions and regulation of its ubiquitously expressed paralog hnRNP DL are barely explored. Here, we present an intricate crosstalk between these two proteins. Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism. Thus, we identified two novel ways of how hnRNP D expression is controlled. The tight interconnection of expression control directly links hnRNP DL to hnRNP D-related diseases and emphasizes the importance of a systematic analysis of its cellular functions.

Item Type: Article
Erschienen: 2018
Creators: Kemmerer, Katrin and Fischer, Sandra and Weigand, Julia E.
Title: Auto- and cross-regulation of the hnRNPs D and DL
Language: English
Abstract:

HnRNP D, better known as AUF1, is an extensively studied protein that controls a variety of cellular pathways. Consequently, its expression has to be tightly regulated to prevent the onset of pathologies. In contrast, the cellular functions and regulation of its ubiquitously expressed paralog hnRNP DL are barely explored. Here, we present an intricate crosstalk between these two proteins. Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism. Thus, we identified two novel ways of how hnRNP D expression is controlled. The tight interconnection of expression control directly links hnRNP DL to hnRNP D-related diseases and emphasizes the importance of a systematic analysis of its cellular functions.

Journal or Publication Title: RNA (New York, N.Y.)
Journal volume: 24
Number: 3
Publisher: Cold Spring Harbor Laboratory Press / RNA Society
Divisions: 10 Department of Biology
10 Department of Biology > RNA Biochemistry
Date Deposited: 05 Mar 2021 07:41
DOI: 10.1261/rna.063420.117
Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824352/
Identification Number: pmid:29263134
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