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Six 1-aroyl-4-(4-methoxyphenyl)piperazines: similar molecular structures but different patterns of supramolecular assembly

Kiran Kumar, Haruvegowda ; Yathirajan, Hemmige S. ; Sagar, Belakavadi K. ; Foro, Sabine ; Glidewell, Christopher (2019):
Six 1-aroyl-4-(4-methoxyphenyl)piperazines: similar molecular structures but different patterns of supramolecular assembly.
In: Acta Crystallographica Section E: Crystallographic Communications, 75 (8), pp. 1253-1260. International Union of Crystallography (IUCr), ISSN 2056-9890,
DOI: 10.1107/S2056989019010491,
[Article]

Abstract

Six new 1-aroyl-4-(4-methoxyphenyl)piperazines have been prepared, using coupling reactions between benzoic acids and N-(4-methoxyphenyl)piperazine. There are no significant hydrogen bonds in the structure of 1-benzoyl-4-(4-methoxyphenyl)piperazine, C1820N2O2, (I). The molecules of 1-(2-fluorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19FN2O2, (II), are linked by two C-H center dot center dot center dot O hydrogen bonds to form chains of rings, which are linked into sheets by an aromatic pi-pi stacking interaction. 1-(2-Chlorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19ClN2O2, (III), 1-(2-bromobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19BrN2O2, (IV), and 1-(2-iodobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19IN2O2, (V), are isomorphous, but in (III) the aroyl ring is disordered over two sets of atomic sites having occupancies of 0.942 (2) and 0.058 (2). In each of (III)-(V), a combination of two C-H center dot center dot center dot pi(arene) hydrogen bonds links the molecules into sheets. A single O-H center dot center dot center dot O hydrogen bond links the molecules of 1 -(2-hydroxybenzoyl)-4-(4-methoxyphenyl)piperazine, C18H20N2O3, (VI), into simple chains. Comparisons are made with the structures of some related compounds.

Item Type: Article
Erschienen: 2019
Creators: Kiran Kumar, Haruvegowda ; Yathirajan, Hemmige S. ; Sagar, Belakavadi K. ; Foro, Sabine ; Glidewell, Christopher
Title: Six 1-aroyl-4-(4-methoxyphenyl)piperazines: similar molecular structures but different patterns of supramolecular assembly
Language: English
Abstract:

Six new 1-aroyl-4-(4-methoxyphenyl)piperazines have been prepared, using coupling reactions between benzoic acids and N-(4-methoxyphenyl)piperazine. There are no significant hydrogen bonds in the structure of 1-benzoyl-4-(4-methoxyphenyl)piperazine, C1820N2O2, (I). The molecules of 1-(2-fluorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19FN2O2, (II), are linked by two C-H center dot center dot center dot O hydrogen bonds to form chains of rings, which are linked into sheets by an aromatic pi-pi stacking interaction. 1-(2-Chlorobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19ClN2O2, (III), 1-(2-bromobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19BrN2O2, (IV), and 1-(2-iodobenzoyl)-4-(4-methoxyphenyl)piperazine, C18H19IN2O2, (V), are isomorphous, but in (III) the aroyl ring is disordered over two sets of atomic sites having occupancies of 0.942 (2) and 0.058 (2). In each of (III)-(V), a combination of two C-H center dot center dot center dot pi(arene) hydrogen bonds links the molecules into sheets. A single O-H center dot center dot center dot O hydrogen bond links the molecules of 1 -(2-hydroxybenzoyl)-4-(4-methoxyphenyl)piperazine, C18H20N2O3, (VI), into simple chains. Comparisons are made with the structures of some related compounds.

Journal or Publication Title: Acta Crystallographica Section E: Crystallographic Communications
Journal volume: 75
Number: 8
Publisher: International Union of Crystallography (IUCr)
Uncontrolled Keywords: Piperazines, crystal structure, isomorphism, disorder, hydrogen bonding, supramolecular assembly
Divisions: 11 Department of Materials and Earth Sciences
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences > Material Science > Structure Research
Date Deposited: 11 Sep 2020 06:41
DOI: 10.1107/S2056989019010491
Official URL: http://scripts.iucr.org/cgi-bin/paper?S2056989019010491
Additional Information:

HSY thanks the University Grants Commission, New Delhi, for the award of a BSR Faculty Fellowship for three years.

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