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Stabilization of Industry-Relevant Enzyme Formulations

Kübelbeck, Sonja (2020):
Stabilization of Industry-Relevant Enzyme Formulations.
Darmstadt, Technische Universität,
DOI: 10.25534/tuprints-00011666,
[Ph.D. Thesis]

Abstract

What do all enzyme-containing liquid detergents have in common, besides their diversity? At the time of washing large parts of all enzymes are already inactive and denatured. Accordingly, the washing performance of the detergent is strongly reduced. There are various causes which lead to this undesirable loss of function. Starting with the presence of surfactants and chelating agents, proteolytic degradation as well as incorrect storage conditions. Known solution approaches focus on the temporal inhibition of protease and neglect the other denaturing factors and enzymes. This thesis deals with four different strategies to stabilize more than just one detergent enzyme against surfactants as well as against proteolysis.

Item Type: Ph.D. Thesis
Erschienen: 2020
Creators: Kübelbeck, Sonja
Title: Stabilization of Industry-Relevant Enzyme Formulations
Language: English
Abstract:

What do all enzyme-containing liquid detergents have in common, besides their diversity? At the time of washing large parts of all enzymes are already inactive and denatured. Accordingly, the washing performance of the detergent is strongly reduced. There are various causes which lead to this undesirable loss of function. Starting with the presence of surfactants and chelating agents, proteolytic degradation as well as incorrect storage conditions. Known solution approaches focus on the temporal inhibition of protease and neglect the other denaturing factors and enzymes. This thesis deals with four different strategies to stabilize more than just one detergent enzyme against surfactants as well as against proteolysis.

Place of Publication: Darmstadt
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Fachgebiet Makromolekulare Chemie
Date Deposited: 08 May 2020 06:34
DOI: 10.25534/tuprints-00011666
Official URL: https://tuprints.ulb.tu-darmstadt.de/11666
URN: urn:nbn:de:tuda-tuprints-116664
Referees: Andrieu-Brunsen, Prof. Dr. Annette ; Meckel, PD Dr. Tobias
Refereed / Verteidigung / mdl. Prüfung: 28 June 2019
Alternative Abstract:
Alternative abstract Language

Was haben alle Flüssigwaschmittel, unabhängig von ihrer Vielfalt, gemeinsam? Zum Zeitpunkt, wenn der Endnutzer seine Waschmaschine startet, sind große Teile der Enzyme im Waschmittel bereits denaturiert und dadurch inaktiv. Zu diesem Funktionsverlust tragen mehrere Faktoren bei: Das Vorhandensein von Tensiden und Chelatbildnern, proteolytischer Abbau und unpassende Lagerbedingungen (Temperatur). Die bekannten Lösungsansätze fokussieren auf die temporäre Inhibierung der Protease und vernachlässigen die anderen vorhandenen Faktoren, die zur Denaturierung führen. Außerdem werden die Waschmittelenzyme neben der Protease nicht in die Stabilisierung mit einbezogen. Die vorliegende Arbeit diskutiert vier Strategien, mit dem Ziel mehr als nur ein Waschmittelenzym gegenüber den Tensiden und der Protease zu stabilisieren.

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