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Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.

Aphasizheva, Inna and Alfonzo, Juan and Carnes, Jason and Cestari, Igor and Cruz-Reyes, Jorge and Göringer, H. Ulrich and Hajduk, Stephen and Lukeš, Julius and Madison-Antenucci, Susan and Maslov, Dmitri A. and McDermott, Suzanne M. and Ochsenreiter, Torsten and Read, Laurie K. and Salavati, Reza and Schnaufer, Achim and Schneider, André and Simpson, Larry and Stuart, Kenneth and Yurchenko, Vyacheslav and Zhou, Z. Hong and Zíková, Alena and Zhang, Liye and Zimmer, Sara and Aphasizhev, Ruslan (2020):
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
In: Trends in parasitology, 36 (4), pp. 337-355. ISSN 1471-5007,
DOI: 10.1016/j.pt.2020.01.006,
[Article]

Abstract

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.

Item Type: Article
Erschienen: 2020
Creators: Aphasizheva, Inna and Alfonzo, Juan and Carnes, Jason and Cestari, Igor and Cruz-Reyes, Jorge and Göringer, H. Ulrich and Hajduk, Stephen and Lukeš, Julius and Madison-Antenucci, Susan and Maslov, Dmitri A. and McDermott, Suzanne M. and Ochsenreiter, Torsten and Read, Laurie K. and Salavati, Reza and Schnaufer, Achim and Schneider, André and Simpson, Larry and Stuart, Kenneth and Yurchenko, Vyacheslav and Zhou, Z. Hong and Zíková, Alena and Zhang, Liye and Zimmer, Sara and Aphasizhev, Ruslan
Title: Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
Language: English
Abstract:

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.

Journal or Publication Title: Trends in parasitology
Journal volume: 36
Number: 4
Divisions: 10 Department of Biology
10 Department of Biology > Postranscriptional Gene Regulation and RNA Therapeutics
Date Deposited: 25 Mar 2020 07:50
DOI: 10.1016/j.pt.2020.01.006
Identification Number: pmid:32191849
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