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Regulation of Eicosanoid Pathways by MicroRNAs.

Saul, Meike J. ; Emmerich, Anne C. ; Steinhilber, Dieter ; Suess, Beatrix (2019):
Regulation of Eicosanoid Pathways by MicroRNAs.
In: Frontiers in pharmacology, 10, p. 824. ISSN 1663-9812,
DOI: 10.3389/fphar.2019.00824,
[Article]

Abstract

Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.

Item Type: Article
Erschienen: 2019
Creators: Saul, Meike J. ; Emmerich, Anne C. ; Steinhilber, Dieter ; Suess, Beatrix
Title: Regulation of Eicosanoid Pathways by MicroRNAs.
Language: English
Abstract:

Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.

Journal or Publication Title: Frontiers in pharmacology
Journal volume: 10
Divisions: 10 Department of Biology
10 Department of Biology > Synthetic Genetic Circuits
Date Deposited: 26 Aug 2019 09:27
DOI: 10.3389/fphar.2019.00824
Identification Number: pmid:31379585
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