Wichmann, Julian L. ; Booz, Christian ; Wesarg, Stefan ; Kafchitsas, Konstantinos ; Bauer, Ralf W. ; Kerl, J. Matthias ; Lehnert, Thomas ; Vogl, Thomas J. ; Khan, M. Fawad (2014)
Dual-Energy CT-based Phantomless in Vivo Three-dimensional Bone Mineral Density Assessment of the Lumbar Spine.
In: Radiology, 271 (3)
doi: 10.1148/radiol.13131952
Article, Bibliographie
Abstract
Purpose: To evaluate the feasibility of phantomless in vivo dual-energy computed tomography (CT)-based three-dimensional (3D) bone mineral density (BMD) assessment in comparison with dual x-ray absorptiometry (DXA). Materials and Methods: This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. Data from clinically indicated dual-energy CT and DXA examinations within 2 months, comprising the lumbar spine of 40 patients, were included. By using automated dedicated postprocessing dual-energy CT software, the trabecular bone of lumbar vertebrae L1-L4 were analyzed and segmented. A mixed-effects model was used to assess the correlations between BMD values derived from dual-energy CT and DXA. Results: One hundred sixty lumbar vertebrae were analyzed in 40 patients (mean age, 57.1 years; range, 24-85 years), 21 male (mean age, 54.3 years; range, 24-85 years) and 19 female (mean age, 58.5 years; range, 31-80 years). Mean BMD of L1-L4 determined with DXA was 0.995 g/ cm², and 18 patients (45) showed an osteoporotic BMD (T score less than 22.5) of at least two vertebrae. Mean dual-energy CT-based BMD of L1-L4 was 0.254 g/cm³. Bland-Altman analysis with mixed effects demonstrated a lack of correlation between dual-energy CT-based and DXA-based BMD values, with a mean difference of 0.7441 and 95 limits of agreement of 0.7441 +/- 0.4080. Conclusion: Dedicated postprocessing of dual-energy CT data allows for phantomless in vivo BMD assessment of the trabecular bone of lumbar vertebrae and enables freely rotatable color-coded 3D visualization of intravertebral BMD distribution.
| Item Type: | Article |
|---|---|
| Erschienen: | 2014 |
| Creators: | Wichmann, Julian L. ; Booz, Christian ; Wesarg, Stefan ; Kafchitsas, Konstantinos ; Bauer, Ralf W. ; Kerl, J. Matthias ; Lehnert, Thomas ; Vogl, Thomas J. ; Khan, M. Fawad |
| Type of entry: | Bibliographie |
| Title: | Dual-Energy CT-based Phantomless in Vivo Three-dimensional Bone Mineral Density Assessment of the Lumbar Spine |
| Language: | English |
| Date: | 2014 |
| Journal or Publication Title: | Radiology |
| Volume of the journal: | 271 |
| Issue Number: | 3 |
| DOI: | 10.1148/radiol.13131952 |
| Abstract: | Purpose: To evaluate the feasibility of phantomless in vivo dual-energy computed tomography (CT)-based three-dimensional (3D) bone mineral density (BMD) assessment in comparison with dual x-ray absorptiometry (DXA). Materials and Methods: This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. Data from clinically indicated dual-energy CT and DXA examinations within 2 months, comprising the lumbar spine of 40 patients, were included. By using automated dedicated postprocessing dual-energy CT software, the trabecular bone of lumbar vertebrae L1-L4 were analyzed and segmented. A mixed-effects model was used to assess the correlations between BMD values derived from dual-energy CT and DXA. Results: One hundred sixty lumbar vertebrae were analyzed in 40 patients (mean age, 57.1 years; range, 24-85 years), 21 male (mean age, 54.3 years; range, 24-85 years) and 19 female (mean age, 58.5 years; range, 31-80 years). Mean BMD of L1-L4 determined with DXA was 0.995 g/ cm², and 18 patients (45) showed an osteoporotic BMD (T score less than 22.5) of at least two vertebrae. Mean dual-energy CT-based BMD of L1-L4 was 0.254 g/cm³. Bland-Altman analysis with mixed effects demonstrated a lack of correlation between dual-energy CT-based and DXA-based BMD values, with a mean difference of 0.7441 and 95 limits of agreement of 0.7441 +/- 0.4080. Conclusion: Dedicated postprocessing of dual-energy CT data allows for phantomless in vivo BMD assessment of the trabecular bone of lumbar vertebrae and enables freely rotatable color-coded 3D visualization of intravertebral BMD distribution. |
| Uncontrolled Keywords: | Business Field: Visual decision support, Research Area: Confluence of graphics and vision, Computed tomography (CT), Computer aided diagnosis, Bone mineral density (BMD), Medical image processing, Medical visualization, Medicine |
| Divisions: | 20 Department of Computer Science 20 Department of Computer Science > Interactive Graphics Systems |
| Date Deposited: | 12 Nov 2018 11:16 |
| Last Modified: | 12 Nov 2018 11:16 |
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