Englisch

Porro, Alessandro ; Saponaro, Andrea ; Castelli, Roberta ; Introini, Bianca ; Hafez Alkotob, Anahita ; Ranjbari, Golnaz ; Enke, Uta ; Kusch, Jana ; Benndorf, Klaus ; Santoro, Bina ; DiFrancesco, Dario ; Thiel, Gerhard ; Moroni, Anna (2024)
A high affinity switch for cAMP in the HCN pacemaker channels.
In: Nature communications, 15 (1)
doi: 10.1038/s41467-024-45136-y
Artikel, Bibliographie

Porro, Alessandro ; Saponaro, Andrea ; Gasparri, Federica ; Bauer, Daniel ; Gross, Christine ; Pisoni, Matteo ; Abbandonato, Gerardo ; Hamacher, Kay ; Santoro, Bina ; Thiel, Gerhard ; Moroni, Anna (2022)
The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels.
In: eLife, 2019, 2019
doi: 10.26083/tuprints-00013344
Artikel, Zweitveröffentlichung, Verlagsversion

Saponaro, Andrea ; Cantini, Francesca ; Porro, Alessandro ; Bucchi, Annalisa ; DiFrancesco, Dario ; Maione, Vincenzo ; Donadoni, Chiara ; Introini, Bianca ; Mesirca, Pietro ; Mangoni, Matteo E. ; Thiel, Gerhard ; Banci, Lucia ; Santoro, Bina ; Moroni, Anna (2022)
A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
In: eLife, 2018, 2018
doi: 10.26083/tuprints-00013339
Artikel, Zweitveröffentlichung, Verlagsversion

Saponaro, Andrea ; Bauer, Daniel ; Giese, M. Hunter ; Swuec, Paolo ; Porro, Alessandro ; Gasparri, Federica ; Sharifzadeh, Atiyeh Sadat ; Chaves-Sanjuan, Antonio ; Alberio, Laura ; Parisi, Giacomo ; Cerutti, Gabriele ; Clarke, Oliver B. ; Hamacher, Kay ; Colecraft, Henry M. ; Mancia, Filippo ; Hendrickson, Wayne A. ; Siegelbaum, Steven A. ; DiFrancesco, Dario ; Bolognesi, Martino ; Thiel, Gerhard ; Santoro, Bina ; Moroni, Anna (2021)
Gating movements and ion permeation in HCN4 pacemaker channels.
In: Molecular cell, 81 (14)
doi: 10.1016/j.molcel.2021.05.033
Artikel, Bibliographie

Porro, Alessandro ; Gasparri, Federica ; Cona, Filippo ; Thiel, Gerhard ; Thei, Federico ; Santoro, Bina ; Saponaro, Andrea ; Moroni, Anna (2020)
The Role of HCN Channel Helices D and E in the Modulation of Camp Affinity.
In: Biophysical Journal, 118 (3)
doi: 10.1016/j.bpj.2019.11.2350
Artikel, Bibliographie

Porro, Alessandro ; Saponaro, Andrea ; Gasparri, Federica ; Bauer, Daniel ; Gross, Christine ; Pisoni, Matteo ; Abbandonato, Gerardo ; Hamacher, Kay ; Santoro, Bina ; Thiel, Gerhard ; Moroni, Anna (2019)
The HCN domain couples voltage gating and cAMP response in Hyperpolarization-activated Cyclic Nucleotide-gated channels.
In: eLife, 8
doi: 10.7554/eLife.49672
Artikel, Bibliographie

Saponaro, Andrea ; Cantini, Francesca ; Porro, Alessandro ; Bucchi, Annalisa ; DiFrancesco, Dario ; Maione, Vincenzo ; Laskowski, Michal ; Mesirca, Pietro ; Mangoni, Matteo ; Thiel, Gerhard ; Banci, Lucia ; Santoro, Bina ; Moroni, Anna (2019)
Developing Synthetic Peptides to Regulate Native HCN Channels.
In: Biophysical Journal, 116 (3)
doi: 10.1016/j.bpj.2018.11.1638
Artikel, Bibliographie

Moroni, Anna ; Porro, Alessandro ; Saponaro, Andrea ; Pisoni, Matteo ; Gasparri, Federica ; Abbandonato, Gerardo ; Thiel, Gerhard ; Santoro, Bina (2019)
The Role of HCN Domain in Channel Gating.
In: Biophysical Journal, 116 (3)
doi: 10.1016/j.bpj.2018.11.2146
Artikel, Bibliographie

Marini, Carla ; Porro, Alessandro ; Rastetter, Agnès ; Dalle, Carine ; Rivolta, Ilaria ; Bauer, Daniel ; Oegema, Renske ; Nava, Caroline ; Parrini, Elena ; Mei, Davide ; Mercer, Catherine ; Dhamija, Radhika ; Chambers, Chelsea ; Coubes, Christine ; Thévenon, Julien ; Kuentz, Paul ; Julia, Sophie ; Pasquier, Laurent ; Dubourg, Christèle ; Carré, Wilfrid ; Rosati, Anna ; Melani, Federico ; Pisano, Tiziana ; Giardino, Maria ; Innes, A. Micheil ; Alembik, Yves ; Scheidecker, Sophie ; Santos, Manuela ; Figueiroa, Sonia ; Garrido, Cristina ; Fusco, Carlo ; Frattini, Daniele ; Spagnoli, Carlotta ; Binda, Anna ; Granata, Tiziana ; Ragona, Francesca ; Freri, Elena ; Franceschetti, Silvana ; Canafoglia, Laura ; Castellotti, Barbara ; Gellera, Cinzia ; Milanesi, Raffaella ; Mancardi, Maria Margherita ; Clark, Damien R. ; Kok, Fernando ; Helbig, Katherine L. ; Ichikawa, Shoji ; Sadler, Laurie ; Neupauerová, Jana ; Laššuthova, Petra ; Šterbová, Katalin ; Laridon, Annick ; Brilstra, Eva ; Koeleman, Bobby ; Lemke, Johannes R. ; Zara, Federico ; Striano, Pasquale ; Soblet, Julie ; Smits, Guillaume ; Deconinck, Nicolas ; Barbuti, Andrea ; DiFrancesco, Dario ; LeGuern, Eric ; Guerrini, Renzo ; Santoro, Bina ; Hamacher, Kay ; Thiel, Gerhard ; Moroni, Anna ; DiFrancesco, Jacopo C. ; Depienne, Christel (2018)
HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.
In: Brain : a journal of neurology, 141 (11)
Artikel, Bibliographie

Groß, Christine ; Saponaro, Andrea ; Santoro, Bina ; Moroni, Anna ; Thiel, Gerhard ; Hamacher, Kay (2018)
Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel.
In: The Journal of biological chemistry, 293 (33)
doi: 10.1074/jbc.RA118.002139
Artikel, Bibliographie

Saponaro, Andrea ; Cantini, Francesca ; Porro, Alessandro ; Bucchi, Annalisa ; DiFrancesco, Dario ; Maione, Vincenzo ; Donadoni, Chiara ; Introini, Bianca ; Mesirca, Pietro ; Mangoni, Matteo Elia ; Thiel, Gerhard ; Banci, Lucia ; Santoro, Bina ; Moroni, Anna (2018)
A synthetic peptide that prevents cAMP regulation in mammalian Hyperpolarization-activated Cyclic Nucleotide-regulated (HCN) channels.
In: eLife, 7
Artikel, Bibliographie

Saponaro, Andrea ; Porro, Alessandro ; Donadoni, Chiara ; Santoro, Bina ; Thiel, Gerhard ; Moroni, Anna (2018)
Assigning Function to the D and E Helices of HCN CNBD.
In: Biophysical journal, 114 (3)
Artikel, Bibliographie

Saponaro, Andrea ; Pauleta, Sofia R. ; Cantini, Francesca ; Matzapetakis, Manolis ; Hammann, Christian ; Donadoni, Chiara ; Hu, Lei ; Thiel, Gerhard ; Banci, Lucia ; Santoro, Bina ; Moroni, Anna (2014)
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
In: Proceedings of the National Academy of Sciences of the United States of America, 11 (40)
Artikel, Bibliographie