Artikel

Philippe, Grégoire Jean-Baptiste ; Huang, Yen-Hua ; Mittermeier, Anna ; Brown, Christopher J. ; Kaas, Quentin ; Ramlan, Siti Radhiah ; Wang, Conan K. ; Lane, David ; Loewer, Alexander ; Troeira Henriques, Sónia ; Craik, David J. (2024)
Delivery to, and reactivation of, the p53 Pathway in cancer cells using a grafted cyclotide conjugated with a cell-penetrating peptide.
In: Journal of medicinal chemistry, 67 (2)
doi: 10.1021/acs.jmedchem.3c01682
Artikel, Bibliographie

Loewer, Alexander (2023)
Virtual stress plays tricks on cells.
In: Cell systems, 14 (7)
doi: 10.1016/j.cels.2023.06.006
Artikel, Bibliographie

Bohn, Stefan ; Hexemer, Lorenz ; Huang, Zixin ; Strohmaier, Laura ; Lenhardt, Sonja ; Legewie, Stefan ; Loewer, Alexander (2023)
State- and stimulus-specific dynamics of SMAD signaling determine fate decisions in individual cells.
In: Proceedings of the National Academy of Sciences of the United States of America, 120 (10)
doi: 10.1073/pnas.2210891120
Artikel, Bibliographie

Konrath, Fabian ; Loewer, Alexander ; Wolf, Jana (2023)
Resolving crosstalk between signaling pathways using mathematical modeling and time-resolved single cell data.
In: Methods in molecular biology (Clifton, N.J.), 2634
doi: 10.1007/978-1-0716-3008-2_12
Artikel, Bibliographie

Kolbe, Niklas ; Hexemer, Lorenz ; Bammert, Lukas-Malte ; Loewer, Alexander ; Lukáčová-Medvid'ová, Mária ; Legewie, Stefan (2022)
Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling.
In: PLoS computational biology, 18 (6)
doi: 10.1371/journal.pcbi.1010266
Artikel, Bibliographie

Friedel, Laura ; Loewer, Alexander (2022)
The guardian's choice: How p53 enables context-specific decision making in individual cells.
In: The FEBS journal, 289 (1)
doi: 10.1111/febs.15767
Artikel, Bibliographie

Philippe, Grégoire J.-B. ; Mittermeier, Anna ; Lawrence, Nicole ; Huang, Yen-Hua ; Condon, Nicholas D. ; Loewer, Alexander ; Craik, David J. ; Henriques, Sónia T. (2021)
Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells.
In: ACS chemical biology, 16 (2)
doi: 10.1021/acschembio.0c00988
Artikel, Bibliographie

Konrath, Fabian ; Mittermeier, Anna ; Cristiano, Elena ; Wolf, Jana ; Loewer, Alexander (2020)
A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
In: PLoS computational biology, 16 (6)
doi: 10.1371/journal.pcbi.1007901
Artikel, Bibliographie

Benary, Manuela ; Bohn, Stefan ; Lüthen, Mareen ; Nolis, Ilias K. ; Blüthgen, Nils ; Loewer, Alexander (2020)
Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging.
In: Cell reports, 31 (2)
doi: 10.1016/j.celrep.2020.03.078
Artikel, Bibliographie

Jentsch, Marcel ; Snyder, Petra ; Sheng, Caibin ; Cristiano, Elena ; Loewer, Alexander (2020)
p53 dynamics in single cells are temperature-sensitive.
In: Scientific Reports, 2020, 10 (1)
doi: 10.25534/tuprints-00011576
Artikel, Zweitveröffentlichung

Friedrich, Dhana ; Friedel, Laura ; Finzel, Ana ; Herrmann, Andreas ; Preibisch, Stephan ; Loewer, Alexander (2020)
Stochastic transcription in the p53‐mediated response to DNA damage is modulated by burst frequency.
In: Molecular Systems Biology, 2019, 15 (12)
doi: 10.25534/tuprints-00011601
Artikel, Zweitveröffentlichung

Friedrich, Dhana ; Friedel, Laura ; Finzel, Ana ; Herrmann, Andreas ; Preibisch, Stephan ; Loewer, Alexander (2019)
Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency.
In: Molecular systems biology, 15 (12)
doi: 10.15252/msb.20199068
Artikel, Bibliographie

Philippe, Grégoire J.-B. ; Gaspar, Diana ; Sheng, Caibin ; Huang, Yen-Hua ; Benfield, Aurélie H. ; Condon, Nicholas D. ; Weidmann, Joachim ; Lawrence, Nicole ; Loewer, Alexander ; Castanho, Miguel A. R. B. ; Craik, David J. ; Troeira Henriques, Sónia (2019)
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix–Loop–Helix Peptides with Cell Penetrating and Tumor Suppressor Properties.
In: ACS Chemical Biology, 14 (9)
doi: 10.1021/acschembio.9b00593
Artikel, Bibliographie

Sheng, Caibin ; Mendler, Isabella-Hilda ; Rieke, Sara ; Snyder, Petra ; Jentsch, Marc ; Friedrich, Dhana ; Drossel, Barbara ; Loewer, Alexander (2019)
PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells.
In: Cell Reports, 27 (1)
doi: 10.1016/j.celrep.2019.03.031
Artikel, Bibliographie

Chamiolo, Jasmine ; Fang, Ge‐min ; Hövelmann, Felix ; Friedrich, Dhana ; Knoll, Andrea ; Loewer, Alexander ; Seitz, Oliver (2019)
Comparing Agent‐Based Delivery of DNA and PNA Forced Intercalation (FIT) Probes for Multicolor mRNA Imaging.
In: ChemBioChem, 20 (4)
doi: 10.1002/cbic.201800526
Artikel, Bibliographie

Fang, Ge-Min ; Chamiolo, Jasmine ; Kankowski, Svenja ; Hövelmann, Felix ; Friedrich, Dhana ; Loewer, Alexander ; Meier, Jochen C. ; Seitz, Oliver (2018)
A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA edit via FRET in a binary system.
In: Chemical science, 9 (21)
Artikel, Bibliographie

Strasen, Jette ; Sarma, Uddipan ; Jentsch, Marcel ; Bohn, Stefan ; Sheng, Caibin ; Horbelt, Daniel ; Knaus, Petra ; Legewie, Stefan ; Loewer, Alexander (2018)
Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.
In: Molecular systems biology, 14 (1)
Artikel, Bibliographie

Batchelor, Eric ; Loewer, Alexander (2017)
Recent progress and open challenges in modeling p53 dynamics in single cells.
In: Current opinion in systems biology, 3
Artikel, Bibliographie

Mönke, Gregor ; Cristiano, Elena ; Finzel, Ana ; Friedrich, Dhana ; Herzel, Hanspeter ; Falcke, Martin ; Loewer, Alexander (2017)
Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
In: Scientific Reports, 2017, 7
doi: 10.1038/srep46571
Artikel, Zweitveröffentlichung

Paek, Andrew L. ; Liu, Julia C. ; Loewer, Alexander ; Forrester, William C. ; Lahav, Galit (2016)
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
In: Cell, 165 (3)
Artikel, Bibliographie

Finzel, Ana ; Grybowski, Andrea ; Strasen, Jette ; Cristiano, Elena ; Loewer, Alexander (2016)
Hyper-activation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.
In: Molecular biology of the cell, 27 (15)
Artikel, Bibliographie

Schrenk-Siemens, Katrin ; Wende, Hagen ; Prato, Vincenzo ; Song, Kun ; Rostock, Charlotte ; Loewer, Alexander ; Utikal, Jochen ; Lewin, Gary R. ; Lechner, Stefan G. ; Siemens, Jan (2015)
PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
In: Nature neuroscience, 18 (1)
Artikel, Bibliographie

Borcherds, Wade ; Theillet, François-Xavier ; Katzer, Andrea ; Finzel, Ana ; Mishall, Katie M. ; Powell, Anne T. ; Wu, Hongwei ; Manieri, Wanda ; Dieterich, Christoph ; Selenko, Philipp ; Loewer, Alexander ; Daughdrill, Gary W. (2014)
Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
In: Nature chemical biology, 10 (12)
Artikel, Bibliographie

González, Erik ; Rother, Marion ; Kerr, Markus C. ; Al-Zeer, Munir A. ; Abu-Lubad, Mohammad ; Kessler, Mirjana ; Brinkmann, Volker ; Loewer, Alexander ; Meyer, Thomas F. (2014)
Chlamydia infection depends on a functional MDM2-p53 axis.
In: Nature communications, 5
Artikel, Bibliographie

Schueler, Markus ; Munschauer, Mathias ; Gregersen, Lea Haarup ; Finzel, Ana ; Loewer, Alexander ; Chen, Wei ; Landthaler, Markus ; Dieterich, Christoph (2014)
Differential protein occupancy profiling of the mRNA transcriptome.
In: Genome biology, 15 (1)
Artikel, Bibliographie

Loewer, Alexander ; Karanam, Ketki ; Mock, Caroline ; Lahav, Galit (2013)
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.
In: BMC biology, 11
Artikel, Bibliographie

Memczak, Sebastian ; Jens, Marvin ; Elefsinioti, Antigoni ; Torti, Francesca ; Krueger, Janna ; Rybak, Agnieszka ; Maier, Luisa ; Mackowiak, Sebastian D. ; Gregersen, Lea H. ; Munschauer, Mathias ; Loewer, Alexander ; Ziebold, Ulrike ; Landthaler, Markus ; Kocks, Christine ; Le Noble, Ferdinand ; Rajewsky, Nikolaus (2013)
Circular RNAs are a large class of animal RNAs with regulatory potency.
In: Nature, 495 (7441)
Artikel, Bibliographie

Karanam, Ketki ; Loewer, Alexander ; Lahav, Galit (2013)
Dynamics of the DNA damage response: insights from live-cell imaging.
In: Briefings in functional genomics, 12 (2)
Artikel, Bibliographie

Karanam, Ketki ; Kafri, Ran ; Loewer, Alexander ; Lahav, Galit (2012)
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.
In: Molecular cell, 47 (2)
Artikel, Bibliographie

Purvis, Jeremy E. ; Karhohs, Kyle W. ; Mock, Caroline ; Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit (2012)
p53 dynamics control cell fate.
In: Science (New York, N.Y.), 336 (6087)
Artikel, Bibliographie

Orth, James D. ; Loewer, Alexander ; Lahav, Galit ; Mitchison, Timothy J. (2012)
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
In: Molecular biology of the cell, 23 (4)
Artikel, Bibliographie

Batchelor, Eric ; Loewer, Alexander ; Mock, Caroline ; Lahav, Galit (2011)
Stimulus-dependent dynamics of p53 in single cells.
In: Molecular systems biology, 7
Artikel, Bibliographie

Loewer, Alexander ; Lahav, Galit (2011)
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
In: Current opinion in genetics & development, 21 (6)
Artikel, Bibliographie

Toettcher, Jared E. ; Mock, Caroline ; Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit (2010)
A synthetic-natural hybrid oscillator in human cells.
In: Proceedings of the National Academy of Sciences of the United States of America, 107 (39)
Artikel, Bibliographie

Loewer, Alexander ; Batchelor, Eric ; Gaglia, Giorgio ; Lahav, Galit (2010)
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
In: Cell, 142 (1)
Artikel, Bibliographie

Stempfle, Denise ; Kanwar, Ritu ; Loewer, Alexander ; Fortini, Mark E. ; Merdes, Gunter (2010)
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
In: Molecular and cellular biology, 30 (13)
Artikel, Bibliographie

Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit (2009)
The ups and downs of p53: understanding protein dynamics in single cells.
In: Nature reviews. Cancer, 9 (5)
Artikel, Bibliographie

Toettcher, Jared E. ; Loewer, Alexander ; Ostheimer, Gerard J. ; Yaffe, Michael B. ; Tidor, Bruce ; Lahav, Galit (2009)
Distinct mechanisms act in concert to mediate cell cycle arrest.
In: Proceedings of the National Academy of Sciences of the United States of America, 106 (3)
Artikel, Bibliographie

Peshkin, L. ; Goni, J. ; Loewer, Alexander ; Kolluri, R. S. ; Lahav, Galit ; Wall, D. (2009)
Morphology from texture in cytometry.
In: IJTS, 16 (s10)
Artikel, Bibliographie

Batchelor, Eric ; Mock, Caroline S. ; Bhan, Irun ; Loewer, Alexander ; Lahav, Galit (2008)
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.
In: Molecular cell, 30 (3)
Artikel, Bibliographie

Rusu, Patricia ; Jansen, Anna ; Soba, Peter ; Kirsch, Joachim ; Loewer, Alexander ; Merdes, Gunter ; Kuan, Yung-Hui ; Jung, Anita ; Beyreuther, Konrad ; Kjaerulff, Ole ; Kins, Stefan (2007)
Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.
In: The European journal of neuroscience, 25 (4)
Artikel, Bibliographie

Loewer, Alexander ; Lahav, Galit (2006)
Cellular conference call: external feedback affects cell-fate decisions.
In: Cell, 124 (6)
Artikel, Bibliographie

Soba, Peter ; Eggert, Simone ; Wagner, Katja ; Zentgraf, Hanswalter ; Siehl, Katjuscha ; Kreger, Sylvia ; Loewer, Alexander ; Langer, Andreas ; Merdes, Gunter ; Paro, Renato ; Masters, Colin L. ; Müller, Ulrike ; Kins, Stefan ; Beyreuther, Konrad (2006)
Cell interactions are promoted by transdimerization of APP family members, arranged as homo- or heterocomplexes in synaptic membranes.
In: The EMBO journal, 25 (3)
Artikel, Bibliographie

Merdes, Gunter ; Soba, Peter ; Loewer, Alexander ; Bilic, Michaela V. ; Beyreuther, Konrad ; Paro, Renato (2004)
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.
In: The EMBO journal, 23 (20)
Artikel, Bibliographie

Loewer, Alexander ; Soba, Peter ; Beyreuther, Konrad ; Paro, Renato ; Merdes, Gunter (2004)
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
In: EMBO reports, 5 (4)
Artikel, Bibliographie

Buchkapitel

Huang, Zixin ; Loewer, Alexander (2022)
Generating Somatic Knockout Cell Lines with CRISPR-Cas9 Technology to Investigate SMAD Signaling.
In: TGF-Beta Signaling : Methods and Protocols
doi: 10.1007/978-1-0716-2277-3_7
Buchkapitel, Bibliographie

Dissertation

Ho, Naphang (2023)
Human myeloid enhanced model systems: Tools for advanced evaluation of short-term CAR T cells and in vivo CAR T cell generation.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00023009
Dissertation, Erstveröffentlichung, Verlagsversion

Smit, Timo Eric (2022)
Kardiotoxizität weltraumrelevanter Schwerionenstrahlung: In vitro Effekte auf Funktion und Pathophysiologie von Kardiomyozyten.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00020924
Dissertation, Erstveröffentlichung, Verlagsversion

Friedel, Laura (2022)
From acute to persisting damage: CHK2 is crucial for sustaining the p53 response.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00021798
Dissertation, Erstveröffentlichung, Verlagsversion

Bohn, Stefan Jürgen (2021)
The Interplay of Signaling Dynamics and Cell Cycle Regulation in Single Cells.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00019077
Dissertation, Erstveröffentlichung, Verlagsversion

Mittermeier, Anna (2021)
Investigating the dynamic rewiring of the p53 network.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00020206
Dissertation, Erstveröffentlichung, Verlagsversion

Patasic, Lea (2020)
DARPin-targeted Chimeric Antigen Receptor T cells: CD4 as a cellular target shows potential to evade HIV latency reservoir.
Technische Universität Darmstadt
doi: 10.25534/tuprints-00013332
Dissertation, Erstveröffentlichung

Jentsch, Marcel (2020)
Computational Approaches to Examine Cellular Signalling Networks.
Technische Universität Darmstadt
doi: 10.25534/tuprints-00011498
Dissertation, Erstveröffentlichung

Erbeldinger, Nadine (2017)
Microvascular Damage as Initial Event of Scar Formation after Carbon Ion Irradiation of Cardiac Substructures.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung