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Rheology of human blood plasma: Viscoelastic versus Newtonian behavior

Brust, M. and Schäfer, C. and Dörr, Roland and Pan, L. and Garcia, M. and Arratia, P.E. and Wagner, C. (2013):
Rheology of human blood plasma: Viscoelastic versus Newtonian behavior.
In: Physical Review Letters, 110, DOI: 10.1103/PhysRevLett.110.078305, [Online-Edition: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.11...],
[Article]

Abstract

We investigate the rheological characteristics of human blood plasma in shear and elongational flows. While we can confirm a Newtonian behavior in shear flow within experimental resolution, we find a viscoelastic behavior of blood plasma in the pure extensional flow of a capillary break-up rheometer. The influence of the viscoelasticity of blood plasma on capillary blood flow is tested in a microfluidic device with a contraction-expansion geometry. Differential pressure measurements revealed that the plasma has a pronounced flow resistance compared to that of pure water. Supple- mentary measurements indicate that the viscoelasticity of the plasma might even lead to viscoelastic instabilities under certain conditions. Our findings show that the viscoelastic properties of plasma should not be ignored in future studies on blood flow.

Item Type: Article
Erschienen: 2013
Creators: Brust, M. and Schäfer, C. and Dörr, Roland and Pan, L. and Garcia, M. and Arratia, P.E. and Wagner, C.
Title: Rheology of human blood plasma: Viscoelastic versus Newtonian behavior
Language: English
Abstract:

We investigate the rheological characteristics of human blood plasma in shear and elongational flows. While we can confirm a Newtonian behavior in shear flow within experimental resolution, we find a viscoelastic behavior of blood plasma in the pure extensional flow of a capillary break-up rheometer. The influence of the viscoelasticity of blood plasma on capillary blood flow is tested in a microfluidic device with a contraction-expansion geometry. Differential pressure measurements revealed that the plasma has a pronounced flow resistance compared to that of pure water. Supple- mentary measurements indicate that the viscoelasticity of the plasma might even lead to viscoelastic instabilities under certain conditions. Our findings show that the viscoelastic properties of plasma should not be ignored in future studies on blood flow.

Journal or Publication Title: Physical Review Letters
Volume: 110
Uncontrolled Keywords: blood, blood plasma, Viscoelastic behavior, Newtonian Behavior, Rheology
Divisions: 18 Department of Electrical Engineering and Information Technology > Institute for Electromechanical Design
18 Department of Electrical Engineering and Information Technology > Institute for Electromechanical Design > Microtechnology and Electromechanical Systems
18 Department of Electrical Engineering and Information Technology
Date Deposited: 07 Nov 2017 08:42
DOI: 10.1103/PhysRevLett.110.078305
Official URL: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.11...
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