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Biofunctionalization of Silsesquioxane Nanoparticles

Hörner, Sebastian (2017):
Biofunctionalization of Silsesquioxane Nanoparticles.
Darmstadt, Technische Universität, [Online-Edition: http://tuprints.ulb.tu-darmstadt.de/6565],
[Ph.D. Thesis]

Abstract

Cube-octameric silsesquioxanes (COSS) were investigated as modular scaffolds for the application in biomedical engineering and associated research areas. Chemical modification of these unique organic-inorganic hybrids endowed them with novel features, aimed at functional tailoring towards executing certain biologic tasks. The chemical and structural peculiarities of COSS nanoparticles were used to address two parallel issues, the first one being development of a viable route to peptide multimers, and the second one – elaboration of a molecular platform for efficient cellular transport.

Item Type: Ph.D. Thesis
Erschienen: 2017
Creators: Hörner, Sebastian
Title: Biofunctionalization of Silsesquioxane Nanoparticles
Language: English
Abstract:

Cube-octameric silsesquioxanes (COSS) were investigated as modular scaffolds for the application in biomedical engineering and associated research areas. Chemical modification of these unique organic-inorganic hybrids endowed them with novel features, aimed at functional tailoring towards executing certain biologic tasks. The chemical and structural peculiarities of COSS nanoparticles were used to address two parallel issues, the first one being development of a viable route to peptide multimers, and the second one – elaboration of a molecular platform for efficient cellular transport.

Place of Publication: Darmstadt
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Fachgebiet Biochemie
07 Department of Chemistry > Fachgebiet Biochemie > Allgemeine Biochemie
Date Deposited: 02 Jul 2017 19:55
Official URL: http://tuprints.ulb.tu-darmstadt.de/6565
URN: urn:nbn:de:tuda-tuprints-65658
Referees: Kolmar, Professor Harald and Neumann, Professor Siegfried
Refereed / Verteidigung / mdl. Prüfung: 27 March 2017
Alternative Abstract:
Alternative abstract Language
Die Dissertationsarbeit behandelt die Erforschung von Silsesquioxan Gerüstmolekülen im Hinblick auf unterschiedliche biomedizinische Anwendungen. Durch die chemische Modifikation dieser einzigartigen organisch-anorganischen Hybridmoleküle konnten verschiedene biologische Effekte erzielt werden. Dabei wurden die chemischen und strukturellen Besonderheiten von Cube-octameric Silsesquioxanen (COSS) verwendet, um zwei Ziele zu erreichen: Erstens die Etablierung einer geeigneten Methode zur Multimerisierung von Peptiden und zweitens, die Entwicklung einer Plattformtechnologie für effizienten Wirkstofftransport.German
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