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Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier.

Baumeister, Dirk ; Hertel, Brigitte ; Schroeder, Indra ; Gazzarrini, Sabrina ; Kast, Stefan M. ; Van Etten, James L. ; Moroni, Anna ; Thiel, Gerhard :
Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier.
In: FEBS letters, 591 (2) pp. 295-303. ISSN 1873-3468
[Artikel], (2017)

Kurzbeschreibung (Abstract)

The miniature channel, Kcv, is a structural equivalent of the pore of all K(+) channels. Here, we follow up on a previous observation that a largely voltage-insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage-sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels.

Typ des Eintrags: Artikel
Erschienen: 2017
Autor(en): Baumeister, Dirk ; Hertel, Brigitte ; Schroeder, Indra ; Gazzarrini, Sabrina ; Kast, Stefan M. ; Van Etten, James L. ; Moroni, Anna ; Thiel, Gerhard
Titel: Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier.
Sprache: Englisch
Kurzbeschreibung (Abstract):

The miniature channel, Kcv, is a structural equivalent of the pore of all K(+) channels. Here, we follow up on a previous observation that a largely voltage-insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage-sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels.

Titel der Zeitschrift, Zeitung oder Schriftenreihe: FEBS letters
Band: 591
(Heft-)Nummer: 2
Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie
10 Fachbereich Biologie > Plant Membrane Biophysics
Hinterlegungsdatum: 04 Jan 2017 11:21
ID-Nummer: pmid:27995608
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