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Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier.

Baumeister, Dirk and Hertel, Brigitte and Schroeder, Indra and Gazzarrini, Sabrina and Kast, Stefan M. and Van Etten, James L. and Moroni, Anna and Thiel, Gerhard (2017):
Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier.
In: FEBS letters, pp. 295-303, 591, (2), ISSN 1873-3468,
[Article]

Abstract

The miniature channel, Kcv, is a structural equivalent of the pore of all K(+) channels. Here, we follow up on a previous observation that a largely voltage-insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage-sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels.

Item Type: Article
Erschienen: 2017
Creators: Baumeister, Dirk and Hertel, Brigitte and Schroeder, Indra and Gazzarrini, Sabrina and Kast, Stefan M. and Van Etten, James L. and Moroni, Anna and Thiel, Gerhard
Title: Conversion of an instantaneous activating K(+) channel into a slow activating inward rectifier.
Language: English
Abstract:

The miniature channel, Kcv, is a structural equivalent of the pore of all K(+) channels. Here, we follow up on a previous observation that a largely voltage-insensitive channel can be converted into a slow activating inward rectifier after extending the outer transmembrane domain by one Ala. This gain of rectification can be rationalized by dynamic salt bridges at the cytosolic entrance to the channel; opening is favored by voltage-sensitive formation of salt bridges and counteracted by their disruption. Such latent voltage sensitivity in the pore could be relevant for the understanding of voltage gating in complex Kv channels.

Journal or Publication Title: FEBS letters
Volume: 591
Number: 2
Divisions: 10 Department of Biology
10 Department of Biology > Plant Membrane Biophysics
Date Deposited: 04 Jan 2017 11:21
Identification Number: pmid:27995608
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