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The putative tumor suppressor gene EphA7 is a novel BMI-1 target.

Prost, Gaëlle ; Braun, Sebastian ; Hertwig, Falk ; Winkler, Marcus ; Jagemann, Lucas ; Nolbrant, Sara ; Leefa, Isabelle V. ; Offen, Nils ; Miharada, Kenichi ; Lang, Stefan ; Artner, Isabella ; Nuber, Ulrike A. (2016):
The putative tumor suppressor gene EphA7 is a novel BMI-1 target.
In: Oncotarget, 7 (36), pp. 58203-58217. ISSN 1949-2553,
[Article]

Abstract

Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do not explain the full spectrum of BMI-1-mediated effects. Here we identify the putative tumor suppressor gene EphA7 as a novel direct BMI-1 target in neural cells and lymphocytes. EphA7 silencing has been reported in several different human tumor types including lymphomas, and our data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation.

Item Type: Article
Erschienen: 2016
Creators: Prost, Gaëlle ; Braun, Sebastian ; Hertwig, Falk ; Winkler, Marcus ; Jagemann, Lucas ; Nolbrant, Sara ; Leefa, Isabelle V. ; Offen, Nils ; Miharada, Kenichi ; Lang, Stefan ; Artner, Isabella ; Nuber, Ulrike A.
Title: The putative tumor suppressor gene EphA7 is a novel BMI-1 target.
Language: English
Abstract:

Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do not explain the full spectrum of BMI-1-mediated effects. Here we identify the putative tumor suppressor gene EphA7 as a novel direct BMI-1 target in neural cells and lymphocytes. EphA7 silencing has been reported in several different human tumor types including lymphomas, and our data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation.

Journal or Publication Title: Oncotarget
Journal volume: 7
Number: 36
Divisions: 10 Department of Biology
10 Department of Biology > Stem Cell and Developmental Biology
Date Deposited: 30 Aug 2016 09:55
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