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Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols

Pérez-Mitta, Gonzalo and Burr, Loïc and Tuninetti, Jimena S. and Trautmann, Christina and Toimil-Molares, María Eugenia and Azzaroni, Omar (2016):
Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols.
In: Nanoscale, The Royal Society of Chemistry Publishing, pp. 1470-1478, 8, (3), ISSN 2040-3364, [Online-Edition: http://dx.doi.org/10.1039/C5NR08190D],
[Article]

Abstract

In recent years there has been increasing interest in the development of new methods for conferring functional features to nanopore-based fluidic devices. In this work, we describe for the first time the noncovalent integration of amphoteric–amphipathic polymers, also known as “amphipols”, into single conical nanopores in order to obtain signal-responsive chemical nanodevices. Highly-tapered conical nanopores were fabricated by single-sided chemical etching of polycarbonate foils. After etching, the surface of the conical nanopores was chemically modified, by first metallizing the surface via gold sputtering and then by amphiphilic self-assembly of the amphipol. The net charge of adsorbed amphipols was regulated via pH changes under the environmental conditions. The pH-dependent chemical equilibrium of the weak acidic and basic monomers facilitates the regulation of the ionic transport through the nanopore by adjusting the pH of the electrolyte solution. Our results demonstrate that functional amphipathic polymers are powerful building blocks for the surface modification of nanopores and might ultimately pave the way to a new means of integrating functional and/or responsive units within nanofluidic structures.

Item Type: Article
Erschienen: 2016
Creators: Pérez-Mitta, Gonzalo and Burr, Loïc and Tuninetti, Jimena S. and Trautmann, Christina and Toimil-Molares, María Eugenia and Azzaroni, Omar
Title: Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols
Language: English
Abstract:

In recent years there has been increasing interest in the development of new methods for conferring functional features to nanopore-based fluidic devices. In this work, we describe for the first time the noncovalent integration of amphoteric–amphipathic polymers, also known as “amphipols”, into single conical nanopores in order to obtain signal-responsive chemical nanodevices. Highly-tapered conical nanopores were fabricated by single-sided chemical etching of polycarbonate foils. After etching, the surface of the conical nanopores was chemically modified, by first metallizing the surface via gold sputtering and then by amphiphilic self-assembly of the amphipol. The net charge of adsorbed amphipols was regulated via pH changes under the environmental conditions. The pH-dependent chemical equilibrium of the weak acidic and basic monomers facilitates the regulation of the ionic transport through the nanopore by adjusting the pH of the electrolyte solution. Our results demonstrate that functional amphipathic polymers are powerful building blocks for the surface modification of nanopores and might ultimately pave the way to a new means of integrating functional and/or responsive units within nanofluidic structures.

Journal or Publication Title: Nanoscale
Volume: 8
Number: 3
Publisher: The Royal Society of Chemistry Publishing
Divisions: 11 Department of Materials and Earth Sciences > Material Science > Ion-Beam-Modified Materials
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences
Date Deposited: 15 Jun 2016 09:01
Official URL: http://dx.doi.org/10.1039/C5NR08190D
Identification Number: doi:10.1039/C5NR08190D
Funders: The authors acknowledge financial support from ANPCyT (PICT 2010-2554 and PICT-2013-0905), Fundación Petruzza., The authors acknowledge financial support from he Austrian Institute of Technology GmbH (AIT – CONICET Partner Lab: “ Exploratory Research for Advanced Technologies in Supramolecular Materials Science ” – Exp. 4947/11, Res. No. 3911, 28-12-2011., The authors acknowledge financial support from the Deutsche Forschungsgemeinschaft (DFG-FOR 1583)., G. P.-M. and J. S. T acknowledge CONICET for a doctoral and a postdoctoral fellowship, respectively. O. A. is a CONICET fellow.
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