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Sensor structure concepts for the analysis or local radiation exposure of biological samples at Terahertz and Millimeter Wave Frequencies

Dornuf, Fabian and Dörr, Roland and Laemmle, David and Schlaak, Helmut F. and Krozer, Viktor (2016):
Sensor structure concepts for the analysis or local radiation exposure of biological samples at Terahertz and Millimeter Wave Frequencies.
In: Photonic West 2016, USA, San Francisco, 13.-18.02.2016, [Conference or Workshop Item]

Abstract

We have studied several sensor concepts for biomedical applications operating in the millimetre-wave and Terahertz range. On one hand, rectangular waveguide structure were designed and extended with microfluidic channels. In this way a simple analysis of aqueous solutions at various waveguide bands is possible. In our case, we focused on the frequency range between 75 GHz and 110 GHz. On the other hand, planar sensor structures for aqueous solutions have been developed based on coplanar waveguides. With these planar sensors it is possible to concentrate the interaction volume on small sensor areas, which achieve a local exposure of the radiation to the sample. When equipping the sensor with microfluidic structures the sample volume could be reduced significantly and enabled a localized interaction with the sensor areas. The sensors are designed to exhibit a broadband behavior up to 300 GHz. Narrow-band operation can also be achieved for potentially increased sensitivity by using resonant structures. Several tests with Glucose solved in water show promising results for the distinction of different glucose levels at millimeter wave frequencies. The planar structures can also be used for the exposure of biological cells or cell model systems like liposomes with electromagnetic radiation. Several studies are planned to distinguish on one hand the influence of millimeter wave exposure on biological systems and also to have a spectroscopic method which enables the analysis of cell processes, like membrane transport processes, with millimeter wave and terahertz frequencies by focusing the electric field directly on the analyzing sample.

Item Type: Conference or Workshop Item
Erschienen: 2016
Creators: Dornuf, Fabian and Dörr, Roland and Laemmle, David and Schlaak, Helmut F. and Krozer, Viktor
Title: Sensor structure concepts for the analysis or local radiation exposure of biological samples at Terahertz and Millimeter Wave Frequencies
Language: English
Abstract:

We have studied several sensor concepts for biomedical applications operating in the millimetre-wave and Terahertz range. On one hand, rectangular waveguide structure were designed and extended with microfluidic channels. In this way a simple analysis of aqueous solutions at various waveguide bands is possible. In our case, we focused on the frequency range between 75 GHz and 110 GHz. On the other hand, planar sensor structures for aqueous solutions have been developed based on coplanar waveguides. With these planar sensors it is possible to concentrate the interaction volume on small sensor areas, which achieve a local exposure of the radiation to the sample. When equipping the sensor with microfluidic structures the sample volume could be reduced significantly and enabled a localized interaction with the sensor areas. The sensors are designed to exhibit a broadband behavior up to 300 GHz. Narrow-band operation can also be achieved for potentially increased sensitivity by using resonant structures. Several tests with Glucose solved in water show promising results for the distinction of different glucose levels at millimeter wave frequencies. The planar structures can also be used for the exposure of biological cells or cell model systems like liposomes with electromagnetic radiation. Several studies are planned to distinguish on one hand the influence of millimeter wave exposure on biological systems and also to have a spectroscopic method which enables the analysis of cell processes, like membrane transport processes, with millimeter wave and terahertz frequencies by focusing the electric field directly on the analyzing sample.

Uncontrolled Keywords: sensor structures, THz radiation, waveguides, microchannels, analysis of cells
Divisions: 18 Department of Electrical Engineering and Information Technology
18 Department of Electrical Engineering and Information Technology > Institute for Electromechanical Design
18 Department of Electrical Engineering and Information Technology > Institute for Electromechanical Design > Microtechnology and Electromechanical Systems
Event Title: Photonic West 2016
Event Location: USA, San Francisco
Event Dates: 13.-18.02.2016
Date Deposited: 07 Mar 2016 16:54
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