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Engineering a ca++-sensitive (bio)sensor from the pore-module of a potassium channel.

DiFrancesco, Mattia Lorenzo and Gazzarrini, Sabrina and Arrigoni, Cristina and Romani, Giulia and Thiel, Gerhard and Moroni, Anna (2015):
Engineering a ca++-sensitive (bio)sensor from the pore-module of a potassium channel.
In: Sensors (Basel, Switzerland), pp. 4913-24, 15, (3), ISSN 1424-8220,
[Article]

Abstract

Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus.

Item Type: Article
Erschienen: 2015
Creators: DiFrancesco, Mattia Lorenzo and Gazzarrini, Sabrina and Arrigoni, Cristina and Romani, Giulia and Thiel, Gerhard and Moroni, Anna
Title: Engineering a ca++-sensitive (bio)sensor from the pore-module of a potassium channel.
Language: English
Abstract:

Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus.

Journal or Publication Title: Sensors (Basel, Switzerland)
Volume: 15
Number: 3
Divisions: 10 Department of Biology
10 Department of Biology > Plant Membrane Biophysics
Date Deposited: 10 Mar 2015 09:24
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