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Magnetic resonance elastography and diffusion-weighted imaging of the sol/gel phase transition in agarose

Sack, I. and Gedat, E. and Bernarding, J. and Buntkowsky, G. and Braun, J. (2004):
Magnetic resonance elastography and diffusion-weighted imaging of the sol/gel phase transition in agarose.
166, In: Journal of Magnetic Resonance, (2), pp. 252-261. [Article]

Abstract

The dynamics of the sol/gel phase transition in agarose was analyzed with magnetic resonance elastography (MRE) and diffusion-weighted imaging, providing complementary information on a microstructural as well as on a macroscopic spatial scale. In thermal equilibrium, the diffusion coefficient of agarose is linearly correlated with temperature, independent of the sol/gel phase transition. In larger agarose samples, the transition from the sol to the gel state was characterized by a complex position and temperature dependency of both MIZE shear wave patterns and apparent diffusion coefficients (ADC). The position dependency of the temperature was experimentally found to be qualitatively similar to the behavior of the ADC maps. The dynamics of the temperature could be described with a simplified model that described the heat exchange between sol and gel compartments. The experiments supported the approach to derive temperature maps from the ADC maps by a linear relationship. The spatially resolved dynamics of the temperature maps were therefore employed to determine the elasticities. For this reason, experimental MRE data were simulated using a model of coupled harmonic oscillators. The calculated images agreed well with the experimentally observed MRE wave patterns. (C) 2003 Elsevier Inc. All rights reserved.

Item Type: Article
Erschienen: 2004
Creators: Sack, I. and Gedat, E. and Bernarding, J. and Buntkowsky, G. and Braun, J.
Title: Magnetic resonance elastography and diffusion-weighted imaging of the sol/gel phase transition in agarose
Language: English
Abstract:

The dynamics of the sol/gel phase transition in agarose was analyzed with magnetic resonance elastography (MRE) and diffusion-weighted imaging, providing complementary information on a microstructural as well as on a macroscopic spatial scale. In thermal equilibrium, the diffusion coefficient of agarose is linearly correlated with temperature, independent of the sol/gel phase transition. In larger agarose samples, the transition from the sol to the gel state was characterized by a complex position and temperature dependency of both MIZE shear wave patterns and apparent diffusion coefficients (ADC). The position dependency of the temperature was experimentally found to be qualitatively similar to the behavior of the ADC maps. The dynamics of the temperature could be described with a simplified model that described the heat exchange between sol and gel compartments. The experiments supported the approach to derive temperature maps from the ADC maps by a linear relationship. The spatially resolved dynamics of the temperature maps were therefore employed to determine the elasticities. For this reason, experimental MRE data were simulated using a model of coupled harmonic oscillators. The calculated images agreed well with the experimentally observed MRE wave patterns. (C) 2003 Elsevier Inc. All rights reserved.

Journal or Publication Title: Journal of Magnetic Resonance
Volume: 166
Number: 2
Uncontrolled Keywords: magnetic resonance elastography diffusion-weighted imaging sol/gel phase transition agarose modulus of elasticity mr elastography skeletal-muscle reconstruction visualization simulation inversion waves
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Physical Chemistry
Date Deposited: 27 Oct 2014 20:48
Official URL: http://apps.webofknowledge.com/full_record.do?product=WOS&se...
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767TU Times Cited:11 Cited References Count:25

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