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Natural products – learning chemistry from plants.

Staniek, Agata and Bouwmeester, Harro and Fraser, Paul D. and Kayser, Oliver and Martens, Stefan and Tissier, Alain and van der Krol, Sander and Wessjohann, Ludger and Warzecha, Heribert (2014):
Natural products – learning chemistry from plants.
In: Biotechnology journal, 9 (3), pp. 326-36, ISSN 1860-7314,
[Article]

Abstract

Plant natural products (PNPs) are unique in that they represent a vast array of different structural features, ranging from relatively simple molecules to very complex ones. Given the fact that many plant secondary metabolites exhibit profound biological activity, they are frequently used as fragrances and flavors, medicines, as well as industrial chemicals. As the intricate structures of PNPs often cannot be mimicked by chemical synthesis, the original plant providers constitute the sole source for their industrial, large-scale production. However, sufficient supply is not guaranteed for all molecules of interest, making the development of alternative production systems a priority. Modern techniques, such as genome mining and thorough biochemical analysis, have helped us gain preliminary understanding of the enzymatic formation of the valuable ingredients in planta. Herein, we review recent advances in the application of biocatalytical processes, facilitating generation of complex PNPs through utilization of plant-derived specific enzymes and combinatorial biochemistry. We further evaluate the options of employing heterologous organisms harboring PNP biosynthetic pathways for the production of secondary metabolites of interest.

Item Type: Article
Erschienen: 2014
Creators: Staniek, Agata and Bouwmeester, Harro and Fraser, Paul D. and Kayser, Oliver and Martens, Stefan and Tissier, Alain and van der Krol, Sander and Wessjohann, Ludger and Warzecha, Heribert
Title: Natural products – learning chemistry from plants.
Language: English
Abstract:

Plant natural products (PNPs) are unique in that they represent a vast array of different structural features, ranging from relatively simple molecules to very complex ones. Given the fact that many plant secondary metabolites exhibit profound biological activity, they are frequently used as fragrances and flavors, medicines, as well as industrial chemicals. As the intricate structures of PNPs often cannot be mimicked by chemical synthesis, the original plant providers constitute the sole source for their industrial, large-scale production. However, sufficient supply is not guaranteed for all molecules of interest, making the development of alternative production systems a priority. Modern techniques, such as genome mining and thorough biochemical analysis, have helped us gain preliminary understanding of the enzymatic formation of the valuable ingredients in planta. Herein, we review recent advances in the application of biocatalytical processes, facilitating generation of complex PNPs through utilization of plant-derived specific enzymes and combinatorial biochemistry. We further evaluate the options of employing heterologous organisms harboring PNP biosynthetic pathways for the production of secondary metabolites of interest.

Journal or Publication Title: Biotechnology journal
Volume: 9
Number: 3
Divisions: 10 Department of Biology
10 Department of Biology > Plant Biotechnology and Metabolic Engineering
Date Deposited: 15 Apr 2014 11:16
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