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Robustness and evolution in oscillatory systems with feedback loops

Hafner, M. and Koeppl, H. and Wagner, A. (2009):
Robustness and evolution in oscillatory systems with feedback loops.
Denver, USA, IEEE, In: Proc. of the Third IEEE International Conference on Foundations of Systems Biology in Engineering (FOSBE), [Online-Edition: http://infoscience.epfl.ch/record/130922?ln=en http://arxiv....],
[Conference or Workshop Item]

Abstract

Feedback loops are major components of biochemical systems. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses address the question how such multiple feedback loops evolved. Based on published models from the mitotic cycle in embryogenesis, we build a few case studies. Using a simple core architecture (transcription, phosphorylation and degradation), we define oscillatory models having either one positive feedback or one negative feedback, or both loops. With these models, we address the following questions about evolvability: could a system evolve from a simple model to a more complex one with a continuous transition in the parameter space? How do new feedback loops emerge without disrupting the proper function of the system? Our results show that progressive formation of a second feedback loop is possible without disturbing existing oscillatory behavior. For this process, the parameters of the system have to change during evolution to maintain predefined properties of oscillations like period and amplitude.

Item Type: Conference or Workshop Item
Erschienen: 2009
Creators: Hafner, M. and Koeppl, H. and Wagner, A.
Title: Robustness and evolution in oscillatory systems with feedback loops
Language: English
Abstract:

Feedback loops are major components of biochemical systems. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses address the question how such multiple feedback loops evolved. Based on published models from the mitotic cycle in embryogenesis, we build a few case studies. Using a simple core architecture (transcription, phosphorylation and degradation), we define oscillatory models having either one positive feedback or one negative feedback, or both loops. With these models, we address the following questions about evolvability: could a system evolve from a simple model to a more complex one with a continuous transition in the parameter space? How do new feedback loops emerge without disrupting the proper function of the system? Our results show that progressive formation of a second feedback loop is possible without disturbing existing oscillatory behavior. For this process, the parameters of the system have to change during evolution to maintain predefined properties of oscillations like period and amplitude.

Place of Publication: Denver, USA
Publisher: IEEE
Uncontrolled Keywords: Oscillators,evolution,feedback loops,robustness
Divisions: 18 Department of Electrical Engineering and Information Technology > Institute for Telecommunications > Bioinspired Communication Systems
18 Department of Electrical Engineering and Information Technology
18 Department of Electrical Engineering and Information Technology > Institute for Telecommunications
Event Title: Proc. of the Third IEEE International Conference on Foundations of Systems Biology in Engineering (FOSBE)
Date Deposited: 04 Apr 2014 13:05
Official URL: http://infoscience.epfl.ch/record/130922?ln=en http://arxiv....
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