TU Darmstadt / ULB / TUbiblio

5-Lipoxygenase mRNA and Protein Isoforms.

Ochs, Meike J. and Suess, Beatrix and Steinhilber, Dieter (2014):
5-Lipoxygenase mRNA and Protein Isoforms.
114, In: Basic & clinical pharmacology & toxicology, (1), pp. 78-82, ISSN 1742-7843, [Article]

Abstract

5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases like asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets. This article is protected by copyright. All rights reserved.

Item Type: Article
Erschienen: 2014
Creators: Ochs, Meike J. and Suess, Beatrix and Steinhilber, Dieter
Title: 5-Lipoxygenase mRNA and Protein Isoforms.
Language: English
Abstract:

5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases like asthma or atherosclerosis. In this MiniReview, we focus on recent findings regarding alternative splice variants of 5-LO with a special emphasis on two potential protein isoforms expressed in human B-lymphocytes which might be of interest as new drug targets. This article is protected by copyright. All rights reserved.

Journal or Publication Title: Basic & clinical pharmacology & toxicology
Volume: 114
Number: 1
Divisions: 10 Department of Biology
10 Department of Biology > Synthetic Genetic Circuits
Date Deposited: 18 Sep 2013 11:10
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)

View Item View Item