Ochs, Meike J. ; Steinhilber, Dieter ; Suess, Beatrix (2014)
MicroRNAs - Novel Therapeutic Targets of Eicosanoid Signalling.
In: Basic & clinical pharmacology & toxicology, 114 (1)
doi: 10.1111/bcpt.12116
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
MicroRNAs (miRNAs) have emerged as important regulators in human physiological and pathological processes. We summarize the current knowledge about the role of miRNA involved in the control of inflammatory responses with a special focus on eicosanoid signalling. Cyclooxygenase 2 - the key enzyme of the prostanoid pathway - is regulated by different miRNAs like miRNA-101, miR199a, miR26b and miR-146a. In contrast to this, the understanding of miRNA regulation on enzymes of the leukotriene biosynthesis is just at the beginning. The knowledge of miRNAs regulating enzymes of the eicosanoid pathway offers a new way for the development of new therapeutic concepts for the treatment of inflammatory diseases. This article is protected by copyright. All rights reserved.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2014 |
| Autor(en): | Ochs, Meike J. ; Steinhilber, Dieter ; Suess, Beatrix |
| Art des Eintrags: | Bibliographie |
| Titel: | MicroRNAs - Novel Therapeutic Targets of Eicosanoid Signalling. |
| Sprache: | Englisch |
| Publikationsjahr: | 2014 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Basic & clinical pharmacology & toxicology |
| Jahrgang/Volume einer Zeitschrift: | 114 |
| (Heft-)Nummer: | 1 |
| DOI: | 10.1111/bcpt.12116 |
| Kurzbeschreibung (Abstract): | MicroRNAs (miRNAs) have emerged as important regulators in human physiological and pathological processes. We summarize the current knowledge about the role of miRNA involved in the control of inflammatory responses with a special focus on eicosanoid signalling. Cyclooxygenase 2 - the key enzyme of the prostanoid pathway - is regulated by different miRNAs like miRNA-101, miR199a, miR26b and miR-146a. In contrast to this, the understanding of miRNA regulation on enzymes of the leukotriene biosynthesis is just at the beginning. The knowledge of miRNAs regulating enzymes of the eicosanoid pathway offers a new way for the development of new therapeutic concepts for the treatment of inflammatory diseases. This article is protected by copyright. All rights reserved. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Synthetic Genetic Circuits (2020 umbenannt in "Synthetic RNA biology") |
| Hinterlegungsdatum: | 27 Aug 2013 11:31 |
| Letzte Änderung: | 28 Jan 2014 12:36 |
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