TU Darmstadt / ULB / TUbiblio

MicroRNAs - Novel Therapeutic Targets of Eicosanoid Signalling.

Ochs, Meike J. and Steinhilber, Dieter and Suess, Beatrix (2014):
MicroRNAs - Novel Therapeutic Targets of Eicosanoid Signalling.
114, In: Basic & clinical pharmacology & toxicology, (1), pp. 92-96, ISSN 1742-7843, [Article]

Abstract

MicroRNAs (miRNAs) have emerged as important regulators in human physiological and pathological processes. We summarize the current knowledge about the role of miRNA involved in the control of inflammatory responses with a special focus on eicosanoid signalling. Cyclooxygenase 2 - the key enzyme of the prostanoid pathway - is regulated by different miRNAs like miRNA-101, miR199a, miR26b and miR-146a. In contrast to this, the understanding of miRNA regulation on enzymes of the leukotriene biosynthesis is just at the beginning. The knowledge of miRNAs regulating enzymes of the eicosanoid pathway offers a new way for the development of new therapeutic concepts for the treatment of inflammatory diseases. This article is protected by copyright. All rights reserved.

Item Type: Article
Erschienen: 2014
Creators: Ochs, Meike J. and Steinhilber, Dieter and Suess, Beatrix
Title: MicroRNAs - Novel Therapeutic Targets of Eicosanoid Signalling.
Language: English
Abstract:

MicroRNAs (miRNAs) have emerged as important regulators in human physiological and pathological processes. We summarize the current knowledge about the role of miRNA involved in the control of inflammatory responses with a special focus on eicosanoid signalling. Cyclooxygenase 2 - the key enzyme of the prostanoid pathway - is regulated by different miRNAs like miRNA-101, miR199a, miR26b and miR-146a. In contrast to this, the understanding of miRNA regulation on enzymes of the leukotriene biosynthesis is just at the beginning. The knowledge of miRNAs regulating enzymes of the eicosanoid pathway offers a new way for the development of new therapeutic concepts for the treatment of inflammatory diseases. This article is protected by copyright. All rights reserved.

Journal or Publication Title: Basic & clinical pharmacology & toxicology
Volume: 114
Number: 1
Divisions: 10 Department of Biology
10 Department of Biology > Synthetic Genetic Circuits
Date Deposited: 27 Aug 2013 11:31
Identification Number: doi:10.1111/bcpt.12116
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)

View Item View Item