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Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators.

Wittmann, Alexander and Suess, Beatrix (2012):
Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators.
586, In: FEBS letters, (15), pp. 2076-83, ISSN 1873-3468, [Article]

Abstract

Riboswitches are natural RNA-based genetic switches that sense small-molecule metabolites and regulate in response the expression of the corresponding metabolic genes. Within the last years, several engineered riboswitches have been developed that act on various stages of gene expression. These switches can be engineered to respond to any ligand of choice and are therefore of great interest for synthetic biology. In this review, we present an overview of engineered riboswitches and discuss their application in conditional gene expression systems. We will provide structural and mechanistic insights and point out problems and recent trends in the development of engineered riboswitches.

Item Type: Article
Erschienen: 2012
Creators: Wittmann, Alexander and Suess, Beatrix
Title: Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators.
Language: English
Abstract:

Riboswitches are natural RNA-based genetic switches that sense small-molecule metabolites and regulate in response the expression of the corresponding metabolic genes. Within the last years, several engineered riboswitches have been developed that act on various stages of gene expression. These switches can be engineered to respond to any ligand of choice and are therefore of great interest for synthetic biology. In this review, we present an overview of engineered riboswitches and discuss their application in conditional gene expression systems. We will provide structural and mechanistic insights and point out problems and recent trends in the development of engineered riboswitches.

Journal or Publication Title: FEBS letters
Volume: 586
Number: 15
Divisions: 10 Department of Biology > Synthetic Genetic Circuits
10 Department of Biology
Date Deposited: 11 Jul 2012 13:22
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