Wittmann, Alexander ; Suess, Beatrix (2012)
Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators.
In: FEBS letters, 586 (15)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Riboswitches are natural RNA-based genetic switches that sense small-molecule metabolites and regulate in response the expression of the corresponding metabolic genes. Within the last years, several engineered riboswitches have been developed that act on various stages of gene expression. These switches can be engineered to respond to any ligand of choice and are therefore of great interest for synthetic biology. In this review, we present an overview of engineered riboswitches and discuss their application in conditional gene expression systems. We will provide structural and mechanistic insights and point out problems and recent trends in the development of engineered riboswitches.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2012 |
| Autor(en): | Wittmann, Alexander ; Suess, Beatrix |
| Art des Eintrags: | Bibliographie |
| Titel: | Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators. |
| Sprache: | Englisch |
| Publikationsjahr: | 2012 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | FEBS letters |
| Jahrgang/Volume einer Zeitschrift: | 586 |
| (Heft-)Nummer: | 15 |
| Kurzbeschreibung (Abstract): | Riboswitches are natural RNA-based genetic switches that sense small-molecule metabolites and regulate in response the expression of the corresponding metabolic genes. Within the last years, several engineered riboswitches have been developed that act on various stages of gene expression. These switches can be engineered to respond to any ligand of choice and are therefore of great interest for synthetic biology. In this review, we present an overview of engineered riboswitches and discuss their application in conditional gene expression systems. We will provide structural and mechanistic insights and point out problems and recent trends in the development of engineered riboswitches. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Synthetic Genetic Circuits (2020 umbenannt in "Synthetic RNA biology") 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 11 Jul 2012 13:22 |
| Letzte Änderung: | 05 Mär 2013 10:01 |
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