Dabouras, Vasili ; Rothermel, Andrée ; Reiniger-Mack, Alexandra ; Wien, Sascha L. ; Layer, Paul G. ; Robitzki, Andrea (2004)
Exogenous application of glucose induces aging in rat cerebral
oligodendrocytes as revealed by alteration in telomere length.
In: Neuroscience letters, 368 (1)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
To investigate aspects of aging on rat oligodendrocytes, cells of an oligodendrocyte cell line, so-called OLN-93, were cultured either in the presence or absence of glucose. Our data demonstrated that glucose-induced aging in vitro caused an elongation and thickening of cell processes and significantly increased the expression of netrin reflecting a more mature state of oligodendrocyte development. A possible age-inducing effect of glucose is also supported by the decrease of ras protein expression and shortening of telomeres in glucose-treated oligodendrocytes. The present study clearly shows that OLN-93 cells are an exciting and suitable model system for the investigation of age-inducing molecules and the analysis of signaling pathways involved in cerebral aging and degenerations. © 2004 Elsevier Ireland Ltd. All rights reserved.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2004 |
| Autor(en): | Dabouras, Vasili ; Rothermel, Andrée ; Reiniger-Mack, Alexandra ; Wien, Sascha L. ; Layer, Paul G. ; Robitzki, Andrea |
| Art des Eintrags: | Bibliographie |
| Titel: | Exogenous application of glucose induces aging in rat cerebral oligodendrocytes as revealed by alteration in telomere length |
| Sprache: | Englisch |
| Publikationsjahr: | 2004 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Neuroscience letters |
| Jahrgang/Volume einer Zeitschrift: | 368 |
| (Heft-)Nummer: | 1 |
| Kurzbeschreibung (Abstract): | To investigate aspects of aging on rat oligodendrocytes, cells of an oligodendrocyte cell line, so-called OLN-93, were cultured either in the presence or absence of glucose. Our data demonstrated that glucose-induced aging in vitro caused an elongation and thickening of cell processes and significantly increased the expression of netrin reflecting a more mature state of oligodendrocyte development. A possible age-inducing effect of glucose is also supported by the decrease of ras protein expression and shortening of telomeres in glucose-treated oligodendrocytes. The present study clearly shows that OLN-93 cells are an exciting and suitable model system for the investigation of age-inducing molecules and the analysis of signaling pathways involved in cerebral aging and degenerations. © 2004 Elsevier Ireland Ltd. All rights reserved. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_zoologie ?? 10 Fachbereich Biologie > Developmental Biology and Neurogenetics |
| Hinterlegungsdatum: | 21 Nov 2011 12:34 |
| Letzte Änderung: | 05 Mär 2013 09:56 |
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