Simon, Jörg ; Hederstedt, Lars (2011)
Composition and function of cytochrome c biogenesis System II.
In: The FEBS journal, 278 (22)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Organisms employ one of several different enzyme systems to mature cytochromes c. The biosynthetic process involves periplasmic reduction of cysteine residues in the haem c attachment motif of the apo-cytochrome, transmembrane transport of haem b and stereospecific covalent haem attachment via thioether bonds. The biogenesis System II (or Ccs system) is employed by β-, δ- and ε-proteobacteria, Gram-positive bacteria, Aquificales, cyanobacteria as well as by algal and plant chloroplasts. System II comprises four (sometimes only three) membrane-bound proteins: CcsA (or ResC) and CcsB (ResB) are the components of the cytochrome c synthase whereas CcdA and CcsX (ResA) function in the generation of a reduced haem c attachment motif. Some ε-proteobacteria contain CcsBA fusion proteins constituting single polypeptide cytochrome c synthases especially amenable for functional studies. This minireview emphasizes recent findings on the structure, function and specificity of individual System II components and outlines future challenges to understand the fascinating post-translational protein maturation process in more detail.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2011 |
| Autor(en): | Simon, Jörg ; Hederstedt, Lars |
| Art des Eintrags: | Bibliographie |
| Titel: | Composition and function of cytochrome c biogenesis System II. |
| Sprache: | Englisch |
| Publikationsjahr: | 2011 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | The FEBS journal |
| Jahrgang/Volume einer Zeitschrift: | 278 |
| (Heft-)Nummer: | 22 |
| Kurzbeschreibung (Abstract): | Organisms employ one of several different enzyme systems to mature cytochromes c. The biosynthetic process involves periplasmic reduction of cysteine residues in the haem c attachment motif of the apo-cytochrome, transmembrane transport of haem b and stereospecific covalent haem attachment via thioether bonds. The biogenesis System II (or Ccs system) is employed by β-, δ- and ε-proteobacteria, Gram-positive bacteria, Aquificales, cyanobacteria as well as by algal and plant chloroplasts. System II comprises four (sometimes only three) membrane-bound proteins: CcsA (or ResC) and CcsB (ResB) are the components of the cytochrome c synthase whereas CcdA and CcsX (ResA) function in the generation of a reduced haem c attachment motif. Some ε-proteobacteria contain CcsBA fusion proteins constituting single polypeptide cytochrome c synthases especially amenable for functional studies. This minireview emphasizes recent findings on the structure, function and specificity of individual System II components and outlines future challenges to understand the fascinating post-translational protein maturation process in more detail. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Microbial Energy Conversion and Biotechnology ?? fb10_mikrobiologie ?? 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 18 Okt 2011 10:06 |
| Letzte Änderung: | 05 Mär 2013 09:55 |
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