Mikosch, Melanie and Homann, Ulrike (2009):
How do ER export motifs work on ion channel trafficking?
In: Current opinion in plant biology, 12 (6), pp. 685-9. ISSN 1879-0356,
[Article]
Abstract
The function of cells is strongly affected by the type and number of ion channels in the plasma membrane. Recent investigations have highlighted the complexity of the regulation of ion channel trafficking and uncovered several trafficking determinants including diacidic ER export motifs that influence surface expression of ion channels. The large number of ion channels for which functional diacidic motifs have already been identified underlines their general importance and has led to increasing research into the molecular function of these motifs. This review will summarize recent progress in identifying the molecular basis for recognition of ER export signals and the physiological relevance of regulated ER export of ion channels and its role in targeting of channel subunits.
| Item Type: | Article |
|---|---|
| Erschienen: | 2009 |
| Creators: | Mikosch, Melanie and Homann, Ulrike |
| Title: | How do ER export motifs work on ion channel trafficking? |
| Language: | English |
| Abstract: | The function of cells is strongly affected by the type and number of ion channels in the plasma membrane. Recent investigations have highlighted the complexity of the regulation of ion channel trafficking and uncovered several trafficking determinants including diacidic ER export motifs that influence surface expression of ion channels. The large number of ion channels for which functional diacidic motifs have already been identified underlines their general importance and has led to increasing research into the molecular function of these motifs. This review will summarize recent progress in identifying the molecular basis for recognition of ER export signals and the physiological relevance of regulated ER export of ion channels and its role in targeting of channel subunits. |
| Journal or Publication Title: | Current opinion in plant biology |
| Journal volume: | 12 |
| Number: | 6 |
| Divisions: | 10 Department of Biology > Plant Cell Biology ?? fb10_botanik ?? 10 Department of Biology |
| Date Deposited: | 31 Aug 2011 08:37 |
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