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How do ER export motifs work on ion channel trafficking?

Mikosch, Melanie and Homann, Ulrike (2009):
How do ER export motifs work on ion channel trafficking?
In: Current opinion in plant biology, pp. 685-9, 12, (6), ISSN 1879-0356, [Article]

Abstract

The function of cells is strongly affected by the type and number of ion channels in the plasma membrane. Recent investigations have highlighted the complexity of the regulation of ion channel trafficking and uncovered several trafficking determinants including diacidic ER export motifs that influence surface expression of ion channels. The large number of ion channels for which functional diacidic motifs have already been identified underlines their general importance and has led to increasing research into the molecular function of these motifs. This review will summarize recent progress in identifying the molecular basis for recognition of ER export signals and the physiological relevance of regulated ER export of ion channels and its role in targeting of channel subunits.

Item Type: Article
Erschienen: 2009
Creators: Mikosch, Melanie and Homann, Ulrike
Title: How do ER export motifs work on ion channel trafficking?
Language: English
Abstract:

The function of cells is strongly affected by the type and number of ion channels in the plasma membrane. Recent investigations have highlighted the complexity of the regulation of ion channel trafficking and uncovered several trafficking determinants including diacidic ER export motifs that influence surface expression of ion channels. The large number of ion channels for which functional diacidic motifs have already been identified underlines their general importance and has led to increasing research into the molecular function of these motifs. This review will summarize recent progress in identifying the molecular basis for recognition of ER export signals and the physiological relevance of regulated ER export of ion channels and its role in targeting of channel subunits.

Journal or Publication Title: Current opinion in plant biology
Volume: 12
Number: 6
Divisions: 10 Department of Biology > Plant Cell Biology
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10 Department of Biology
Date Deposited: 31 Aug 2011 08:37
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