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A potassium channel protein encoded by chlorella virus PBCV-1.

Plugge, B. ; Gazzarrini, S. ; Nelson, M. ; Cerana, R. ; Etten, James L. van ; Derst, C. ; DiFrancesco, D. ; Moroni, Anna ; Thiel, Gerhard (2000)
A potassium channel protein encoded by chlorella virus PBCV-1.
In: Science (New York, N.Y.), 287 (5458)
Artikel, Bibliographie

Kurzbeschreibung (Abstract)

The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle.

Typ des Eintrags: Artikel
Erschienen: 2000
Autor(en): Plugge, B. ; Gazzarrini, S. ; Nelson, M. ; Cerana, R. ; Etten, James L. van ; Derst, C. ; DiFrancesco, D. ; Moroni, Anna ; Thiel, Gerhard
Art des Eintrags: Bibliographie
Titel: A potassium channel protein encoded by chlorella virus PBCV-1.
Sprache: Englisch
Publikationsjahr: 2000
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Science (New York, N.Y.)
Jahrgang/Volume einer Zeitschrift: 287
(Heft-)Nummer: 5458
Kurzbeschreibung (Abstract):

The large chlorella virus PBCV-1, which contains double-stranded DNA (dsDNA), encodes a 94-codon open reading frame (ORF) that contains a motif resembling the signature sequence of the pore domain of potassium channel proteins. Phylogenetic analyses of the encoded protein, Kcv, indicate a previously unidentified type of potassium channel. The messenger RNA encoded by the ORF leads to functional expression of a potassium-selective conductance in Xenopus laevis oocytes. The channel blockers amantadine and barium, but not cesium, inhibit this conductance, in addition to virus plaque formation. Thus, PBCV-1 encodes the first known viral protein that functions as a potassium-selective channel and is essential in the virus life cycle.

Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie
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10 Fachbereich Biologie > Plant Membrane Biophyscis (am 20.12.23 umbenannt in Biologie der Algen und Protozoen)
Hinterlegungsdatum: 22 Jun 2011 07:33
Letzte Änderung: 20 Aug 2021 09:43
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