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Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.

Chatelain, Franck C. and Gazzarrini, Sabrina and Fujiwara, Yuichiro and Arrigoni, Cristina and Domigan, Courtney and Ferrara, Giuseppina and Pantoja, Carlos and Thiel, Gerhard and Moroni, Anna and Minor, Daniel L. (2009):
Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.
In: PloS one, pp. e7496, 4, (10), ISSN 1932-6203,
[Article]

Abstract

The data support the idea that permeant ions have an integral role in stabilizing potassium channel structure, suggest that both barium and amantadine act at a similar site, and demonstrate how genetic selections can be used to map blocker binding sites and reveal mechanistic features.

Item Type: Article
Erschienen: 2009
Creators: Chatelain, Franck C. and Gazzarrini, Sabrina and Fujiwara, Yuichiro and Arrigoni, Cristina and Domigan, Courtney and Ferrara, Giuseppina and Pantoja, Carlos and Thiel, Gerhard and Moroni, Anna and Minor, Daniel L.
Title: Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.
Language: English
Abstract:

The data support the idea that permeant ions have an integral role in stabilizing potassium channel structure, suggest that both barium and amantadine act at a similar site, and demonstrate how genetic selections can be used to map blocker binding sites and reveal mechanistic features.

Journal or Publication Title: PloS one
Volume: 4
Number: 10
Divisions: 10 Department of Biology > Plant Membrane Biophysics
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10 Department of Biology
Date Deposited: 21 Jun 2011 11:58
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