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Minimal art: or why small viral K(+) channels are good tools for understanding basic structure and function relations.

Thiel, Gerhard and Baumeister, Dirk and Schroeder, Indra and Kast, Stefan M. and Van Etten, James L. and Moroni, Anna (2011):
Minimal art: or why small viral K(+) channels are good tools for understanding basic structure and function relations.
In: Biochimica et biophysica acta, pp. 580-8, 1808, (2), ISSN 0006-3002,
[Article]

Abstract

Some algal viruses contain genes that encode proteins with the hallmarks of K(+) channels. One feature of these proteins is that they are less than 100 amino acids in size, which make them truly minimal for a K(+) channel protein. That is, they consist of only the pore module present in more complex K(+) channels. The combination of miniature size and the functional robustness of the viral K(+) channels make them ideal model systems for studying how K(+) channels work. Here we summarize recent structure/function correlates from these channels, which provide insight into functional properties such as gating, pharmacology and sorting in cells.

Item Type: Article
Erschienen: 2011
Creators: Thiel, Gerhard and Baumeister, Dirk and Schroeder, Indra and Kast, Stefan M. and Van Etten, James L. and Moroni, Anna
Title: Minimal art: or why small viral K(+) channels are good tools for understanding basic structure and function relations.
Language: English
Abstract:

Some algal viruses contain genes that encode proteins with the hallmarks of K(+) channels. One feature of these proteins is that they are less than 100 amino acids in size, which make them truly minimal for a K(+) channel protein. That is, they consist of only the pore module present in more complex K(+) channels. The combination of miniature size and the functional robustness of the viral K(+) channels make them ideal model systems for studying how K(+) channels work. Here we summarize recent structure/function correlates from these channels, which provide insight into functional properties such as gating, pharmacology and sorting in cells.

Journal or Publication Title: Biochimica et biophysica acta
Volume: 1808
Number: 2
Divisions: 10 Department of Biology > Plant Membrane Biophysics
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10 Department of Biology
Date Deposited: 21 Jun 2011 11:57
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