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The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.

Henkel, Michael and Mitzner, David and Henklein, Peter and Meyer-Almes, Franz-Josef and Moroni, Anna and Difrancesco, Mattia L. and Henkes, Leonhard M. and Kreim, Michael and Kast, Stefan M. and Schubert, Ulrich and Thiel, Gerhard (2010):
The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.
In: PloS one, pp. e11112, 5, (6), ISSN 1932-6203,
[Article]

Abstract

The data support the idea that PB1-F2 is able to form protein channel pores with no appreciable selectivity in membranes and that the c-terminus is important for this function. This information could be important for drug development.

Item Type: Article
Erschienen: 2010
Creators: Henkel, Michael and Mitzner, David and Henklein, Peter and Meyer-Almes, Franz-Josef and Moroni, Anna and Difrancesco, Mattia L. and Henkes, Leonhard M. and Kreim, Michael and Kast, Stefan M. and Schubert, Ulrich and Thiel, Gerhard
Title: The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.
Language: English
Abstract:

The data support the idea that PB1-F2 is able to form protein channel pores with no appreciable selectivity in membranes and that the c-terminus is important for this function. This information could be important for drug development.

Journal or Publication Title: PloS one
Volume: 5
Number: 6
Divisions: 10 Department of Biology > Plant Membrane Biophysics
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10 Department of Biology
Date Deposited: 21 Jun 2011 11:56
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