Urich, Tim ; Gomes, Cláudio M. ; Kletzin, Arnulf ; Frazão, Carlos (2006)
X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme.
In: Science (New York, N.Y.), 311 (5763)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Numerous microorganisms oxidize sulfur for energy conservation and contribute to the global biogeochemical sulfur cycle. We have determined the 1.7 angstrom-resolution structure of the sulfur oxygenase reductase from the thermoacidophilic archaeon Acidianus ambivalens, which catalyzes an oxygen-dependent disproportionation of elemental sulfur. Twenty-four monomers form a large hollow sphere enclosing a positively charged nanocompartment. Apolar channels provide access for linear sulfur species. A cysteine persulfide and a low-potential mononuclear non-heme iron site ligated by a 2-His-1-carboxylate facial triad in a pocket of each subunit constitute the active sites, accessible from the inside of the sphere. The iron is likely the site of both sulfur oxidation and sulfur reduction.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2006 |
| Autor(en): | Urich, Tim ; Gomes, Cláudio M. ; Kletzin, Arnulf ; Frazão, Carlos |
| Art des Eintrags: | Bibliographie |
| Titel: | X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme. |
| Sprache: | Englisch |
| Publikationsjahr: | 2006 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Science (New York, N.Y.) |
| Jahrgang/Volume einer Zeitschrift: | 311 |
| (Heft-)Nummer: | 5763 |
| Kurzbeschreibung (Abstract): | Numerous microorganisms oxidize sulfur for energy conservation and contribute to the global biogeochemical sulfur cycle. We have determined the 1.7 angstrom-resolution structure of the sulfur oxygenase reductase from the thermoacidophilic archaeon Acidianus ambivalens, which catalyzes an oxygen-dependent disproportionation of elemental sulfur. Twenty-four monomers form a large hollow sphere enclosing a positively charged nanocompartment. Apolar channels provide access for linear sulfur species. A cysteine persulfide and a low-potential mononuclear non-heme iron site ligated by a 2-His-1-carboxylate facial triad in a pocket of each subunit constitute the active sites, accessible from the inside of the sphere. The iron is likely the site of both sulfur oxidation and sulfur reduction. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Sulfur Biochemistry and Microbial Bioenergetics ?? fb10_mikrobiologie ?? 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 24 Mai 2011 08:20 |
| Letzte Änderung: | 05 Mär 2013 09:48 |
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