Mason, H. S. ; Warzecha, Heribert ; Mor, T. ; Arntzen, C. J. (2002)
Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine.
In: Trends in molecular medicine, 8 (7)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The use of edible plants for the production and delivery of vaccine proteins could provide an economical alternative to fermentation systems. Genes encoding bacterial and viral antigens are faithfully expressed in edible tissues to form immunogenic proteins. Studies in animals and humans have shown that ingestion of transgenic plants containing vaccine proteins causes production of antigen-specific antibodies in serum and mucosal secretions. In general, the technology is limited by low expression levels for nuclear-integrated transgenes, but recent progress in plant organelle transformation shows promise for enhanced expression. The stability and immunogenicity of orally delivered antigens vary greatly, which necessitates further study on protein engineering to enhance mucosal delivery. These issues are discussed with regard to the further development of plant-based vaccine technology.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2002 |
| Autor(en): | Mason, H. S. ; Warzecha, Heribert ; Mor, T. ; Arntzen, C. J. |
| Art des Eintrags: | Bibliographie |
| Titel: | Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. |
| Sprache: | Englisch |
| Publikationsjahr: | 2002 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Trends in molecular medicine |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| (Heft-)Nummer: | 7 |
| Kurzbeschreibung (Abstract): | The use of edible plants for the production and delivery of vaccine proteins could provide an economical alternative to fermentation systems. Genes encoding bacterial and viral antigens are faithfully expressed in edible tissues to form immunogenic proteins. Studies in animals and humans have shown that ingestion of transgenic plants containing vaccine proteins causes production of antigen-specific antibodies in serum and mucosal secretions. In general, the technology is limited by low expression levels for nuclear-integrated transgenes, but recent progress in plant organelle transformation shows promise for enhanced expression. The stability and immunogenicity of orally delivered antigens vary greatly, which necessitates further study on protein engineering to enhance mucosal delivery. These issues are discussed with regard to the further development of plant-based vaccine technology. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Plant Biotechnology and Metabolic Engineering ?? fb10_botanik ?? 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 17 Mär 2011 11:07 |
| Letzte Änderung: | 05 Mär 2013 09:46 |
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