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Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.

Glenz, K. ; Bouchon, B. ; Stehle, T. ; Wallich, R. ; Simon, M. M. ; Warzecha, Heribert (2006)
Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.
In: Nature biotechnology, 24 (1)
Artikel, Bibliographie

Kurzbeschreibung (Abstract)

Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.

Typ des Eintrags: Artikel
Erschienen: 2006
Autor(en): Glenz, K. ; Bouchon, B. ; Stehle, T. ; Wallich, R. ; Simon, M. M. ; Warzecha, Heribert
Art des Eintrags: Bibliographie
Titel: Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.
Sprache: Englisch
Publikationsjahr: 2006
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Nature biotechnology
Jahrgang/Volume einer Zeitschrift: 24
(Heft-)Nummer: 1
Kurzbeschreibung (Abstract):

Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.

Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie > Plant Biotechnology and Metabolic Engineering
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10 Fachbereich Biologie
Hinterlegungsdatum: 17 Mär 2011 11:01
Letzte Änderung: 05 Mär 2013 09:46
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