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FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb.

Niswander, L. ; Tickle, C. ; Vogel, A. ; Booth, I. ; Martin, G. R. (1993)
FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb.
In: Cell, 75 (3)
Artikel, Bibliographie

Kurzbeschreibung (Abstract)

The apical ectodermal ridge plays a key role in limb development. We show that recombinant FGF-4 can substitute for the ridge to provide all the signals necessary for virtually complete outgrowth and patterning of the chick limb. FGF-4 stimulates proliferation of cells in the distal mesenchyme and maintains a signal from the posterior to the distal mesenchyme that appears to be required for elaboration of skeletal elements in the normal proximodistal sequence. Moreover, retinoic acid, which is capable of providing polarizing activity, can supply this signal. This suggests that polarizing activity plays a role in patterning along the proximodistal axis, in addition to its well-established role in anteroposterior patterning. Taken together, the data suggest a simple mechanism whereby FGF-4 links growth and pattern formation during limb development.

Typ des Eintrags: Artikel
Erschienen: 1993
Autor(en): Niswander, L. ; Tickle, C. ; Vogel, A. ; Booth, I. ; Martin, G. R.
Art des Eintrags: Bibliographie
Titel: FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb.
Sprache: Englisch
Publikationsjahr: 1993
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Cell
Jahrgang/Volume einer Zeitschrift: 75
(Heft-)Nummer: 3
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Kurzbeschreibung (Abstract):

The apical ectodermal ridge plays a key role in limb development. We show that recombinant FGF-4 can substitute for the ridge to provide all the signals necessary for virtually complete outgrowth and patterning of the chick limb. FGF-4 stimulates proliferation of cells in the distal mesenchyme and maintains a signal from the posterior to the distal mesenchyme that appears to be required for elaboration of skeletal elements in the normal proximodistal sequence. Moreover, retinoic acid, which is capable of providing polarizing activity, can supply this signal. This suggests that polarizing activity plays a role in patterning along the proximodistal axis, in addition to its well-established role in anteroposterior patterning. Taken together, the data suggest a simple mechanism whereby FGF-4 links growth and pattern formation during limb development.

Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie > Developmental Biology and Neurogenetics
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10 Fachbereich Biologie
Hinterlegungsdatum: 24 Jan 2011 10:40
Letzte Änderung: 05 Mär 2013 09:44
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