Kostakopoulou, K. ; Vogel, A. ; Brickell, P. ; Tickle, C. (1996)
'Regeneration' of wing bud stumps of chick embryos and reactivation of Msx-1 and Shh expression in response to FGF-4 and ridge signals.
In: Mechanisms of development, 55 (2)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
We examined systematically the ability of chick limb bud stumps to regenerate distal structures when fibroblast growth factor (FGF)-4 is applied. When amputations were made within 600 mu m of the tip and FGF-4 applied either posteriorly or both apically and posteriorly, outgrowth of stump tissues occurred and a virtually complete skeleton developed. 'Regeneration' of distal structures was correlated with reactivation of Msx-1 and Shh expression. At proximal amputation levels where FGF-4 did not lead to 'regeneration', neither Msx-1 nor Shh expression was induced. We also grafted cells from progressively more proximal levels of mouse limb buds to chick wing bud tips beneath the apical ridge and the pattern of reactivation of Msx-1 expression along the proximal distal axis of the limb buds was similar to that found in chick limb buds.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 1996 |
| Autor(en): | Kostakopoulou, K. ; Vogel, A. ; Brickell, P. ; Tickle, C. |
| Art des Eintrags: | Bibliographie |
| Titel: | 'Regeneration' of wing bud stumps of chick embryos and reactivation of Msx-1 and Shh expression in response to FGF-4 and ridge signals. |
| Sprache: | Englisch |
| Publikationsjahr: | 1996 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Mechanisms of development |
| Jahrgang/Volume einer Zeitschrift: | 55 |
| (Heft-)Nummer: | 2 |
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| Kurzbeschreibung (Abstract): | We examined systematically the ability of chick limb bud stumps to regenerate distal structures when fibroblast growth factor (FGF)-4 is applied. When amputations were made within 600 mu m of the tip and FGF-4 applied either posteriorly or both apically and posteriorly, outgrowth of stump tissues occurred and a virtually complete skeleton developed. 'Regeneration' of distal structures was correlated with reactivation of Msx-1 and Shh expression. At proximal amputation levels where FGF-4 did not lead to 'regeneration', neither Msx-1 nor Shh expression was induced. We also grafted cells from progressively more proximal levels of mouse limb buds to chick wing bud tips beneath the apical ridge and the pattern of reactivation of Msx-1 expression along the proximal distal axis of the limb buds was similar to that found in chick limb buds. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Developmental Biology and Neurogenetics ?? fb10_zoologie ?? 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 24 Jan 2011 10:40 |
| Letzte Änderung: | 05 Mär 2013 09:44 |
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