Gräf, Stefan ; Borisova, Branimira E. ; Nellen, Wolfgang ; Steger, Gerhard ; Hammann, Christian (2004)
A database search for double-strand containing RNAs in Dictyostelium discoideum.
In: Biological chemistry, 385 (10)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
In eukaryotic cells, double-stranded RNA is degraded to 21mers and triggers RNA interference. Using a pattern description language, we have searched the EMBL database for sequences with the potential to form double strands in cis in Dictyostelium discoideum. No extended inverted repeats were found in mRNAs. However, the antisense direction of some mRNAs encoding regulatory or developmentally regulated proteins showed the ability to form double-stranded regions. In EST archives, we found potential double strands derived from a few genes, but these transcripts are not continuously encoded in the genome. Most likely, they represent hybrid molecules of sense and antisense RNAs.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2004 |
| Autor(en): | Gräf, Stefan ; Borisova, Branimira E. ; Nellen, Wolfgang ; Steger, Gerhard ; Hammann, Christian |
| Art des Eintrags: | Bibliographie |
| Titel: | A database search for double-strand containing RNAs in Dictyostelium discoideum. |
| Sprache: | Englisch |
| Publikationsjahr: | 2004 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Biological chemistry |
| Jahrgang/Volume einer Zeitschrift: | 385 |
| (Heft-)Nummer: | 10 |
| Kurzbeschreibung (Abstract): | In eukaryotic cells, double-stranded RNA is degraded to 21mers and triggers RNA interference. Using a pattern description language, we have searched the EMBL database for sequences with the potential to form double strands in cis in Dictyostelium discoideum. No extended inverted repeats were found in mRNAs. However, the antisense direction of some mRNAs encoding regulatory or developmentally regulated proteins showed the ability to form double-stranded regions. In EST archives, we found potential double strands derived from a few genes, but these transcripts are not continuously encoded in the genome. Most likely, they represent hybrid molecules of sense and antisense RNAs. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_mikrobiologie ?? 10 Fachbereich Biologie > Regulatorische RNAs und Ribozyme |
| Hinterlegungsdatum: | 29 Jul 2010 12:21 |
| Letzte Änderung: | 05 Mär 2013 09:34 |
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