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A database search for double-strand containing RNAs in Dictyostelium discoideum.

Gräf, Stefan and Borisova, Branimira E. and Nellen, Wolfgang and Steger, Gerhard and Hammann, Christian (2004):
A database search for double-strand containing RNAs in Dictyostelium discoideum.
In: Biological chemistry, pp. 961-5, 385, (10), ISSN 1431-6730, [Article]

Abstract

In eukaryotic cells, double-stranded RNA is degraded to 21mers and triggers RNA interference. Using a pattern description language, we have searched the EMBL database for sequences with the potential to form double strands in cis in Dictyostelium discoideum. No extended inverted repeats were found in mRNAs. However, the antisense direction of some mRNAs encoding regulatory or developmentally regulated proteins showed the ability to form double-stranded regions. In EST archives, we found potential double strands derived from a few genes, but these transcripts are not continuously encoded in the genome. Most likely, they represent hybrid molecules of sense and antisense RNAs.

Item Type: Article
Erschienen: 2004
Creators: Gräf, Stefan and Borisova, Branimira E. and Nellen, Wolfgang and Steger, Gerhard and Hammann, Christian
Title: A database search for double-strand containing RNAs in Dictyostelium discoideum.
Language: English
Abstract:

In eukaryotic cells, double-stranded RNA is degraded to 21mers and triggers RNA interference. Using a pattern description language, we have searched the EMBL database for sequences with the potential to form double strands in cis in Dictyostelium discoideum. No extended inverted repeats were found in mRNAs. However, the antisense direction of some mRNAs encoding regulatory or developmentally regulated proteins showed the ability to form double-stranded regions. In EST archives, we found potential double strands derived from a few genes, but these transcripts are not continuously encoded in the genome. Most likely, they represent hybrid molecules of sense and antisense RNAs.

Journal or Publication Title: Biological chemistry
Volume: 385
Number: 10
Divisions: 10 Department of Biology
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10 Department of Biology > Ribogenetics
Date Deposited: 29 Jul 2010 12:21
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