Pape, Susanne ; Hoffgaard, Franziska ; Hamacher, Kay (2010)
Distance-dependent classification of amino acids by information theory.
In: Proteins: Structure, Function, and Bioinformatics, 78 (10)
doi: 10.1002/prot.22744
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Reduced amino acid alphabets are useful to understand molecular evolution as they reveal basal, shared properties of amino acids, which the structures and functions of proteins rely on. Several previous studies derived such reduced alphabets and linked them to the origin of life and biotechnological applications. However, all this previous work presupposes that only direct contacts of amino acids in native protein structures are relevant. We show in this work, using information-theoretical measures, that an appropriate alphabet reduction scheme is in fact a function of the maximum distance amino acids interact at. Although for small distances our results agree with previous ones, we show how long-range interactions change the overall picture and prompt for a revised understanding of the protein design process.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2010 |
| Autor(en): | Pape, Susanne ; Hoffgaard, Franziska ; Hamacher, Kay |
| Art des Eintrags: | Bibliographie |
| Titel: | Distance-dependent classification of amino acids by information theory |
| Sprache: | Englisch |
| Publikationsjahr: | 2010 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Proteins: Structure, Function, and Bioinformatics |
| Jahrgang/Volume einer Zeitschrift: | 78 |
| (Heft-)Nummer: | 10 |
| DOI: | 10.1002/prot.22744 |
| Kurzbeschreibung (Abstract): | Reduced amino acid alphabets are useful to understand molecular evolution as they reveal basal, shared properties of amino acids, which the structures and functions of proteins rely on. Several previous studies derived such reduced alphabets and linked them to the origin of life and biotechnological applications. However, all this previous work presupposes that only direct contacts of amino acids in native protein structures are relevant. We show in this work, using information-theoretical measures, that an appropriate alphabet reduction scheme is in fact a function of the maximum distance amino acids interact at. Although for small distances our results agree with previous ones, we show how long-range interactions change the overall picture and prompt for a revised understanding of the protein design process. |
| Freie Schlagworte: | Bioinformatik |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_mikrobiologie ?? 10 Fachbereich Biologie > Computational Biology and Simulation 20 Fachbereich Informatik |
| Hinterlegungsdatum: | 21 Jun 2010 17:07 |
| Letzte Änderung: | 30 Apr 2018 11:02 |
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