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A novel isoform of the smooth muscle cell differentiation marker smoothelin.

Krämer, J. and Aguirre-Arteta, A. M. and Thiel, C. and Gross, C. M. and Dietz, R. and Cardoso, M Cristina and Leonhardt, H. (1999):
A novel isoform of the smooth muscle cell differentiation marker smoothelin.
In: Journal of molecular medicine, 77 (2), pp. 294-8, ISSN 0946-2716,
[Online-Edition: http://www.cardoso-lab.org/publications/Kraemer_1999.PDF],
[Article]

Abstract

Studies on smooth muscle cell differentiation and those on vascular development in mouse and humans have long been hampered by the lack of suitable markers. Here we describe a novel, large isoform of smoothelin, a structural protein of differentiated, contractile smooth muscle cells. The protein, which is highly conserved in mouse and humans, shows homology with other cytoskeleton-associated smooth muscle cell proteins and contains an actinin-type actin-binding domain. Northern blot analysis from various mouse organs identified short and long smoothelin mRNA forms, which exhibit distinct tissue expression patterns. The short form is highly expressed in visceral muscle tissues such as intestine and stomach and is not detectable in brain, while the long mRNA form is expressed in all vascularized organs. These results may provide new tools and approaches to study both smooth muscle cell differentiation and proliferative vascular disease.

Item Type: Article
Erschienen: 1999
Creators: Krämer, J. and Aguirre-Arteta, A. M. and Thiel, C. and Gross, C. M. and Dietz, R. and Cardoso, M Cristina and Leonhardt, H.
Title: A novel isoform of the smooth muscle cell differentiation marker smoothelin.
Language: German
Abstract:

Studies on smooth muscle cell differentiation and those on vascular development in mouse and humans have long been hampered by the lack of suitable markers. Here we describe a novel, large isoform of smoothelin, a structural protein of differentiated, contractile smooth muscle cells. The protein, which is highly conserved in mouse and humans, shows homology with other cytoskeleton-associated smooth muscle cell proteins and contains an actinin-type actin-binding domain. Northern blot analysis from various mouse organs identified short and long smoothelin mRNA forms, which exhibit distinct tissue expression patterns. The short form is highly expressed in visceral muscle tissues such as intestine and stomach and is not detectable in brain, while the long mRNA form is expressed in all vascularized organs. These results may provide new tools and approaches to study both smooth muscle cell differentiation and proliferative vascular disease.

Journal or Publication Title: Journal of molecular medicine
Volume: 77
Number: 2
Divisions: 10 Department of Biology
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10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 05 Mar 2010 15:52
Official URL: http://www.cardoso-lab.org/publications/Kraemer_1999.PDF
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